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Molecules 2010, 15(4), 2759-2770; doi:10.3390/molecules15042759
Review

Essential Oil of Myrtus communis L. as a Potential Antioxidant and Antimutagenic Agents

1,* , 1, 1, 2, 2, 1, 1 and 3
Received: 20 January 2010; in revised form: 9 February 2010 / Accepted: 1 March 2010 / Published: 15 April 2010
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Abstract: The present study describes DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity and antimutagenic properties of the essential oil of myrtle (Myrtus communis L.). Plant samples were collected from the two distant localities (southernmost and northern point) of the Montenegro coastline. Chemical profiles of the two samples were evaluated by GC-MS. In both of the samples monoterpenes were found to be the predominant compounds. Among them a-pinene, linalool, 1,8-cineole, and myrtenyl acetate were the major compounds. Significant differences between the samples were found in the ranges of a-pinene (14.7%–35.9%) and myrtenyl acetate (5.4%–21.6%). Both oils exhibited moderate DPPH scavenging activity, with IC50 values of 6.24 mg/mL and 5.99 mg/mL. The antimutagenic properties were assayed against spontaneous and t-BOOH-induced mutagenesis in Escherichia coli oxyR mutant IC202, a bacterial strain deficient in removing ROS. Reduction of the spontaneous mutagenesis in presence of myrtle EO was only slight, up to 13% at the highest concentration tested. When the oxidative mutagen was used, EO expressed higher reduction of mutagenesis, in a concentration dependent manner, with statistical significance for effect at the highest concentration tested (28%). Suppression of t-BOOH induced mutagenesis was correlated with the observed scavenging activity.
Keywords: Myrtus communis L.; essential oil; a-pinene; 1,8-cineole; myrtenyl acetate; mutagenesis; DPPH test Myrtus communis L.; essential oil; a-pinene; 1,8-cineole; myrtenyl acetate; mutagenesis; DPPH test
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Mimica-Dukić, N.; Bugarin, D.; Grbović, S.; Mitić-Ćulafić, D.; Vuković-Gačić, B.; Orčić, D.; Jovin, E.; Couladis, M. Essential Oil of Myrtus communis L. as a Potential Antioxidant and Antimutagenic Agents. Molecules 2010, 15, 2759-2770.

AMA Style

Mimica-Dukić N, Bugarin D, Grbović S, Mitić-Ćulafić D, Vuković-Gačić B, Orčić D, Jovin E, Couladis M. Essential Oil of Myrtus communis L. as a Potential Antioxidant and Antimutagenic Agents. Molecules. 2010; 15(4):2759-2770.

Chicago/Turabian Style

Mimica-Dukić, Neda; Bugarin, Dušan; Grbović, Slavenko; Mitić-Ćulafić, Dragana; Vuković-Gačić, Branka; Orčić, Dejan; Jovin, Emilija; Couladis, Maria. 2010. "Essential Oil of Myrtus communis L. as a Potential Antioxidant and Antimutagenic Agents." Molecules 15, no. 4: 2759-2770.



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