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Chemical Composition and Biological Properties of Rhododendron anthopogon Essential Oil
Department of Pharmaceutical Sciences, University of Padova, Via F. Marzolo, 5, 35131 Padova, Italy
Department of Life Sciences, Microbiology Section, University of Trieste, Via Fleming, 22, 34127 Trieste, Italy
Department of Materials and Natural Resources, University of Trieste, Via A. Valerio 6, 34127 Trieste, Italy
Resource Research and Development Center, Kathmandu, Nepal
Department of Pharmacology and Anaesthesiology, University of Padova, L.go E. Meneghetti 2, 35131 Padova, Italy
Hutchison-MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK
* Author to whom correspondence should be addressed.
Received: 2 February 2010; in revised form: 16 March 2010 / Accepted: 29 March 2010 / Published: 31 March 2010
Abstract: The essential oil of Rhododendron anthopogon was investigated by GC-MS, and seventeen compounds (representing approximately 98% of the oil) were identified. The major components of the aerial parts of the oil were the monoterpenes α-pinene, β-pinene, limonene and the sesquiterpene δ-cadinene. Biological studies revealed a weak topical anti-inflammatory activity; a significant killing effect against some Gram-positive reference strains: Staphylococcus aureus, Enterococcusfecalis, Bacillus subtilis was measured; Mycobacterium tuberculosis reference strain and a clinical isolate of Candida, C. pseudotropicalis were killed by as low as 0.04% (v/v) essential oil. Moreover, the oil was able to reduce cancer cell growth independently of the cell line and the treatment protocols used.
Keywords: Rhododendron anthopogon;GC-MS; essential oil; antimicrobial activity; topical anti-inflammatory activity; antiproliferative activity
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Innocenti, G.; Dall’Acqua, S.; Scialino, G.; Banfi, E.; Sosa, S.; Gurung, K.; Barbera, M.; Carrara, M. Chemical Composition and Biological Properties of Rhododendron anthopogon Essential Oil. Molecules 2010, 15, 2326-2338.
Innocenti G, Dall’Acqua S, Scialino G, Banfi E, Sosa S, Gurung K, Barbera M, Carrara M. Chemical Composition and Biological Properties of Rhododendron anthopogon Essential Oil. Molecules. 2010; 15(4):2326-2338.
Innocenti, Gabbriella; Dall’Acqua, Stefano; Scialino, Giuditta; Banfi, Elena; Sosa, Silvio; Gurung, Khilendra; Barbera, Mariagnese; Carrara, Maria. 2010. "Chemical Composition and Biological Properties of Rhododendron anthopogon Essential Oil." Molecules 15, no. 4: 2326-2338.