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Molecules 2010, 15(4), 2326-2338; doi:10.3390/molecules15042326
Article

Chemical Composition and Biological Properties of Rhododendron anthopogon Essential Oil

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1 Department of Pharmaceutical Sciences, University of Padova, Via F. Marzolo, 5, 35131 Padova, Italy 2 Department of Life Sciences, Microbiology Section, University of Trieste, Via Fleming, 22, 34127 Trieste, Italy 3 Department of Materials and Natural Resources, University of Trieste, Via A. Valerio 6, 34127 Trieste, Italy 4 Resource Research and Development Center, Kathmandu, Nepal 5 Department of Pharmacology and Anaesthesiology, University of Padova, L.go E. Meneghetti 2, 35131 Padova, Italy 6 Hutchison-MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK
* Author to whom correspondence should be addressed.
Received: 2 February 2010 / Revised: 16 March 2010 / Accepted: 29 March 2010 / Published: 31 March 2010
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Abstract

The essential oil of Rhododendron anthopogon was investigated by GC-MS, and seventeen compounds (representing approximately 98% of the oil) were identified. The major components of the aerial parts of the oil were the monoterpenes α-pinene, β-pinene, limonene and the sesquiterpene δ-cadinene. Biological studies revealed a weak topical anti-inflammatory activity; a significant killing effect against some Gram-positive reference strains: Staphylococcus aureus, Enterococcusfecalis, Bacillus subtilis was measured; Mycobacterium tuberculosis reference strain and a clinical isolate of Candida, C. pseudotropicalis were killed by as low as 0.04% (v/v) essential oil. Moreover, the oil was able to reduce cancer cell growth independently of the cell line and the treatment protocols used.
Keywords: Rhododendron anthopogon;GC-MS; essential oil; antimicrobial activity; topical anti-inflammatory activity; antiproliferative activity Rhododendron anthopogon; GC-MS; essential oil; antimicrobial activity; topical anti-inflammatory activity; antiproliferative activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Innocenti, G.; Dall’Acqua, S.; Scialino, G.; Banfi, E.; Sosa, S.; Gurung, K.; Barbera, M.; Carrara, M. Chemical Composition and Biological Properties of Rhododendron anthopogon Essential Oil. Molecules 2010, 15, 2326-2338.

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