Molecules 2010, 15(4), 2326-2338; doi:10.3390/molecules15042326
Article

Chemical Composition and Biological Properties of Rhododendron anthopogon Essential Oil

1 Department of Pharmaceutical Sciences, University of Padova, Via F. Marzolo, 5, 35131 Padova, Italy 2 Department of Life Sciences, Microbiology Section, University of Trieste, Via Fleming, 22, 34127 Trieste, Italy 3 Department of Materials and Natural Resources, University of Trieste, Via A. Valerio 6, 34127 Trieste, Italy 4 Resource Research and Development Center, Kathmandu, Nepal 5 Department of Pharmacology and Anaesthesiology, University of Padova, L.go E. Meneghetti 2, 35131 Padova, Italy 6 Hutchison-MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK
* Author to whom correspondence should be addressed.
Received: 2 February 2010; in revised form: 16 March 2010 / Accepted: 29 March 2010 / Published: 31 March 2010
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Abstract: The essential oil of Rhododendron anthopogon was investigated by GC-MS, and seventeen compounds (representing approximately 98% of the oil) were identified. The major components of the aerial parts of the oil were the monoterpenes α-pinene, β-pinene, limonene and the sesquiterpene δ-cadinene. Biological studies revealed a weak topical anti-inflammatory activity; a significant killing effect against some Gram-positive reference strains: Staphylococcus aureus, Enterococcusfecalis, Bacillus subtilis was measured; Mycobacterium tuberculosis reference strain and a clinical isolate of Candida, C. pseudotropicalis were killed by as low as 0.04% (v/v) essential oil. Moreover, the oil was able to reduce cancer cell growth independently of the cell line and the treatment protocols used.
Keywords: Rhododendron anthopogon;GC-MS; essential oil; antimicrobial activity; topical anti-inflammatory activity; antiproliferative activity

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MDPI and ACS Style

Innocenti, G.; Dall’Acqua, S.; Scialino, G.; Banfi, E.; Sosa, S.; Gurung, K.; Barbera, M.; Carrara, M. Chemical Composition and Biological Properties of Rhododendron anthopogon Essential Oil. Molecules 2010, 15, 2326-2338.

AMA Style

Innocenti G, Dall’Acqua S, Scialino G, Banfi E, Sosa S, Gurung K, Barbera M, Carrara M. Chemical Composition and Biological Properties of Rhododendron anthopogon Essential Oil. Molecules. 2010; 15(4):2326-2338.

Chicago/Turabian Style

Innocenti, Gabbriella; Dall’Acqua, Stefano; Scialino, Giuditta; Banfi, Elena; Sosa, Silvio; Gurung, Khilendra; Barbera, Mariagnese; Carrara, Maria. 2010. "Chemical Composition and Biological Properties of Rhododendron anthopogon Essential Oil." Molecules 15, no. 4: 2326-2338.

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