Chemical Constituents of Excoecaria acerifolia and Their Bioactivities
Abstract
:1. Introduction
2. Results and Discussion
Position | δC | δH | Position | δC | δH |
---|---|---|---|---|---|
1a | 30.2 (t) | 1.18 (m) | 11a | 19.2 (t) | 1.12 (m) |
1b | 1.58 (m) | 11b | 1.49 (m) | ||
2a | 24.5 (t) | 1.61 (m) | 12a | 34.9 (t) | 1.18 (m) |
2b | 1.40 (m) | 12b | 1.58 (m) | ||
3 | 98.6 (s) | / | 13 | 42.1 (d) | 2.19 (d, 5.7) |
4 | 43.9 (s) | / | 14a | 44.7 (t) | 1.12 (m) |
5 | 45.9 (d) | 1.43(m) | 14b | 1.49 (m) | |
6a | 20.6 (t) | 1.12 (m) | 15 | 133.3 (d) | 5.04 (s) |
6b | 1.49 (m) | 16 | 142.4 (s) | / | |
7a | 36.4 (t) | 1.78 (m) | 17 | 15.4 (q) | 1.68 (s) |
7b | 1.53 (m) | 18a | 70.2 (t) | 3.66 (d, 11.0) | |
8 | 48.2 (s) | / | 18b | 3.30 (d, 11.0) | |
9 | 43.8 (d) | 1.46 (m) | 19 | 13.4 (q) | 1.15 (s) |
10 | 36.5 (s) | / | 20a | 68.0 (t) | 4.43 (dd, 8.5, 2.0) |
20b | 3.86 (dd, 8.5, 2.0) |
Biological Acticity
Compound | Concentration (μg/mL) | Intersegmental Vessels (ISV) | Inhibition Ratio (%) |
---|---|---|---|
1 | 100 | 24.7 ± 1.2 | 8.0 |
2 | 100 | 26.7 ± 1.2 | 0.5 |
3 | 100 | 26.0 ± 0.0 | 3.0 |
4 | 100 | 24.7 ± 1.2 | 8.0 |
5 | 100 | 24.7 ± 1.2 | 8.0 |
6 | 100 | 20.0 ± 2.8 | 25.4 |
9 | 50 | 9.4 ± 8.4 ** | 64.9 |
10 | 100 | 26.7 ± 1.2 | 0.5 |
11 | 100 | 26.7 ± 1.2 | 0.5 |
12 | 100 | 26.3 ± 1.5 | 1.7 |
13 | 100 | 24.7 ± 0.6 | 8.0 |
14 | 100 | 26.3 ± 0.6 | 1.7 |
15 | 100 | 25.0 ± 0.0 | 6.7 |
16 | 100 | 24.7 ± 2.3 | 8.0 |
17 | 100 | 27.0 ± 1.0 | 0 |
control a | 26.8 ± 1.8 | ||
PTK787 | 10 | 0 ** | 100 |
M(%) a/ Compounds | Concentration | ||
---|---|---|---|
25 μg/mL | 50 μg/mL | 100 μg/mL | |
4 | 12.78 ± 6.56 | 40.8 ± 2.96** | 52.51 ± 2.97** |
6 | 14.35 ± 0.61** | 48.76 ± 5.08** | 62.03 ± 5.72** |
10 | 15.92 ± 3.12** | 61.13 ± 2.49** | 74.6 ± 2.28** |
11 | 22.38 ± 8.37 | 26.47 ± 5.25** | 48.6 ± 6.76** |
3. Experimental
3.1. General
3.2. Plant Material
3.3. Extraction and Isolation
3.4. Antiangiogenesis and antiproliferative assays
3.4.1. Antiangiogenesis [23]
3.4.2. Antiproliferative [24]
4. Conclusions
Acknowledgements
- Sample Availability: Samples of the compounds 1-17 are available from the authors.
References and Notes
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Zhao, Y.-L.; He, Q.-X.; Li, Y.; Wang, S.-F.; Liu, K.-C.; Yang, Y.-P.; Li, X.-L. Chemical Constituents of Excoecaria acerifolia and Their Bioactivities. Molecules 2010, 15, 2178-2186. https://doi.org/10.3390/molecules15042178
Zhao Y-L, He Q-X, Li Y, Wang S-F, Liu K-C, Yang Y-P, Li X-L. Chemical Constituents of Excoecaria acerifolia and Their Bioactivities. Molecules. 2010; 15(4):2178-2186. https://doi.org/10.3390/molecules15042178
Chicago/Turabian StyleZhao, Yan-Li, Qiu-Xia He, Yang Li, Si-Feng Wang, Ke-Chun Liu, Yong-Ping Yang, and Xiao-Li Li. 2010. "Chemical Constituents of Excoecaria acerifolia and Their Bioactivities" Molecules 15, no. 4: 2178-2186. https://doi.org/10.3390/molecules15042178