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Molecules 2010, 15(4), 2178-2186; doi:10.3390/molecules15042178
Communication

Chemical Constituents of Excoecaria acerifolia and Their Bioactivities

1,2
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3
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3
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1,4,*  and 1,4,*
Received: 29 December 2009 / Revised: 12 February 2010 / Accepted: 8 March 2010 / Published: 26 March 2010
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Abstract

A new kaurane diterpenoid, 3α,18-dihydroxy-3β,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of compounds 1-6 and 9-17 were evaluated using a zebrafish model, with compound 9 being active in this bioassay. At the same time, compounds 4, 6, 10, 11 showed activity in inhibiting the growth of A549 lung cancer cells, and the compound 10 also showed apoptosis-inducing effects on A549 lung cancer cells.
Keywords: kaurane diterpenoid; Excoecaria acerifolia; NMR; antiangiogenic; antiproliferative kaurane diterpenoid; Excoecaria acerifolia; NMR; antiangiogenic; antiproliferative
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhao, Y.-L.; He, Q.-X.; Li, Y.; Wang, S.-F.; Liu, K.-C.; Yang, Y.-P.; Li, X.-L. Chemical Constituents of Excoecaria acerifolia and Their Bioactivities. Molecules 2010, 15, 2178-2186.

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