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Chemical Constituents of Excoecaria acerifolia and Their Bioactivities
¨Laboratory of Ethnobotany, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, China
Graduate University of Chinese Academy of Sciences, Beijing 100039, China
Biology Institute of Shandong Academy of Sciences, Jinan 250014, Shandong, China
Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, China
* Authors to whom correspondence should be addressed.
Received: 29 December 2009; in revised form: 12 February 2010 / Accepted: 8 March 2010 / Published: 26 March 2010
Abstract: A new kaurane diterpenoid, 3α,18-dihydroxy-3β,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of compounds 1-6 and 9-17 were evaluated using a zebrafish model, with compound 9 being active in this bioassay. At the same time, compounds 4, 6, 10, 11 showed activity in inhibiting the growth of A549 lung cancer cells, and the compound 10 also showed apoptosis-inducing effects on A549 lung cancer cells.
Keywords: kaurane diterpenoid; Excoecaria acerifolia; NMR; antiangiogenic; antiproliferative
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MDPI and ACS Style
Zhao, Y.-L.; He, Q.-X.; Li, Y.; Wang, S.-F.; Liu, K.-C.; Yang, Y.-P.; Li, X.-L. Chemical Constituents of Excoecaria acerifolia and Their Bioactivities. Molecules 2010, 15, 2178-2186.
Zhao Y-L, He Q-X, Li Y, Wang S-F, Liu K-C, Yang Y-P, Li X-L. Chemical Constituents of Excoecaria acerifolia and Their Bioactivities. Molecules. 2010; 15(4):2178-2186.
Zhao, Yan-Li; He, Qiu-Xia; Li, Yang; Wang, Si-Feng; Liu, Ke-Chun; Yang, Yong-Ping; Li, Xiao-Li. 2010. "Chemical Constituents of Excoecaria acerifolia and Their Bioactivities." Molecules 15, no. 4: 2178-2186.