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Molecules 2010, 15(3), 2028-2038; doi:10.3390/molecules15032028
Article

Acetamide Derivatives with Antioxidant Activity and Potential Anti-Inflammatory Activity

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Received: 2 February 2010 / Revised: 9 March 2010 / Accepted: 18 March 2010 / Published: 23 March 2010
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Abstract

This study reports the synthesis and antioxidant activity of some new acetamide derivatives. The compounds’ structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS radical and estimating ROS and NO production in tBOH- or LPS-stimulated J774.A1 macrophages. All compounds were tested for their effect on cell viability by an MTT assay and by a Brine Shrimp Test.
Keywords: amides; antioxidant; antiproliferative activity; brine shrimp test amides; antioxidant; antiproliferative activity; brine shrimp test
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Autore, G.; Caruso, A.; Marzocco, S.; Nicolaus, B.; Palladino, C.; Pinto, A.; Popolo, A.; Sinicropi, M.S.; Tommonaro, G.; Saturnino, C. Acetamide Derivatives with Antioxidant Activity and Potential Anti-Inflammatory Activity. Molecules 2010, 15, 2028-2038.

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