Molecules 2010, 15(3), 2028-2038; doi:10.3390/molecules15032028
Article

Acetamide Derivatives with Antioxidant Activity and Potential Anti-Inflammatory Activity

Giuseppina Autore 1 email, Anna Caruso 1 email, Stefania Marzocco 1 email, Barbara Nicolaus 2 email, Chiara Palladino 1 email, Aldo Pinto 1 email, Ada Popolo 1 email, Maria S. Sinicropi 3 email, Giuseppina Tommonaro 2 email and Carmela Saturnino 1,* email
1 Department of Pharmaceutical Sciences, University of Salerno, Fisciano (SA), Italy 2 Institute of Biomolecular Chemistry, CNR, Pozzuoli (NA), Italy 3 Department of Pharmaceutical Sciences, University of Cosenza, Arcavacate di Rende (CS), Italy
* Author to whom correspondence should be addressed.
Received: 2 February 2010; in revised form: 9 March 2010 / Accepted: 18 March 2010 / Published: 23 March 2010
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Abstract: This study reports the synthesis and antioxidant activity of some new acetamide derivatives. The compounds’ structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS radical and estimating ROS and NO production in tBOH- or LPS-stimulated J774.A1 macrophages. All compounds were tested for their effect on cell viability by an MTT assay and by a Brine Shrimp Test.
Keywords: amides; antioxidant; antiproliferative activity; brine shrimp test

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MDPI and ACS Style

Autore, G.; Caruso, A.; Marzocco, S.; Nicolaus, B.; Palladino, C.; Pinto, A.; Popolo, A.; Sinicropi, M.S.; Tommonaro, G.; Saturnino, C. Acetamide Derivatives with Antioxidant Activity and Potential Anti-Inflammatory Activity. Molecules 2010, 15, 2028-2038.

AMA Style

Autore G, Caruso A, Marzocco S, Nicolaus B, Palladino C, Pinto A, Popolo A, Sinicropi MS, Tommonaro G, Saturnino C. Acetamide Derivatives with Antioxidant Activity and Potential Anti-Inflammatory Activity. Molecules. 2010; 15(3):2028-2038.

Chicago/Turabian Style

Autore, Giuseppina; Caruso, Anna; Marzocco, Stefania; Nicolaus, Barbara; Palladino, Chiara; Pinto, Aldo; Popolo, Ada; Sinicropi, Maria S.; Tommonaro, Giuseppina; Saturnino, Carmela. 2010. "Acetamide Derivatives with Antioxidant Activity and Potential Anti-Inflammatory Activity." Molecules 15, no. 3: 2028-2038.

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