Molecules 2010, 15(3), 1903-1917; doi:10.3390/molecules15031903
Article

Design, Synthesis and Anti-HIV Integrase Evaluation of N-(5-Chloro-8-Hydroxy-2-Styrylquinolin-7-yl)Benzenesulfonamide Derivatives

Zi-Guo Jiaoemail, Hong-Qiu He, Cheng-Chu Zeng* email, Jian-Jun Tan, Li-Ming Hu and Cun-Xin Wang* email
College of Life Science & Bioengineering, Beijing University of Technology, Beijing, China
* Authors to whom correspondence should be addressed.
Received: 21 October 2009; in revised form: 8 December 2009 / Accepted: 14 December 2009 / Published: 16 March 2010
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Abstract: Styrylquinoline derivatives are demonstrated to be HIV-1 integrase inhibitors. On the basis of our previous CoMFA analysis of a series of styrylquinoline derivatives, N-[(2-substituted-styryl)-5-chloro-8-hydroxyquinolin-7-yl]-benzenesulfonamide derivatives were designed and synthesized,and their possible HIV IN inhibitory activity was evaluated.
Keywords: styrylquinoline derivatives; HIV-1 IN inhibitors; N-(styryl-8-hydroxyquinolin-7-yl)-benzenesulfonamide derivatives

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Cite This Article

MDPI and ACS Style

Jiao, Z.-G.; He, H.-Q.; Zeng, C.-C.; Tan, J.-J.; Hu, L.-M.; Wang, C.-X. Design, Synthesis and Anti-HIV Integrase Evaluation of N-(5-Chloro-8-Hydroxy-2-Styrylquinolin-7-yl)Benzenesulfonamide Derivatives. Molecules 2010, 15, 1903-1917.

AMA Style

Jiao Z-G, He H-Q, Zeng C-C, Tan J-J, Hu L-M, Wang C-X. Design, Synthesis and Anti-HIV Integrase Evaluation of N-(5-Chloro-8-Hydroxy-2-Styrylquinolin-7-yl)Benzenesulfonamide Derivatives. Molecules. 2010; 15(3):1903-1917.

Chicago/Turabian Style

Jiao, Zi-Guo; He, Hong-Qiu; Zeng, Cheng-Chu; Tan, Jian-Jun; Hu, Li-Ming; Wang, Cun-Xin. 2010. "Design, Synthesis and Anti-HIV Integrase Evaluation of N-(5-Chloro-8-Hydroxy-2-Styrylquinolin-7-yl)Benzenesulfonamide Derivatives." Molecules 15, no. 3: 1903-1917.

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