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Molecules 2010, 15(3), 1903-1917; doi:10.3390/molecules15031903
Article

Design, Synthesis and Anti-HIV Integrase Evaluation of N-(5-Chloro-8-Hydroxy-2-Styrylquinolin-7-yl)Benzenesulfonamide Derivatives

,
, * , ,  and *
College of Life Science & Bioengineering, Beijing University of Technology, Beijing, China
* Authors to whom correspondence should be addressed.
Received: 21 October 2009 / Revised: 8 December 2009 / Accepted: 14 December 2009 / Published: 16 March 2010
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Abstract

Styrylquinoline derivatives are demonstrated to be HIV-1 integrase inhibitors. On the basis of our previous CoMFA analysis of a series of styrylquinoline derivatives, N-[(2-substituted-styryl)-5-chloro-8-hydroxyquinolin-7-yl]-benzenesulfonamide derivatives were designed and synthesized,and their possible HIV IN inhibitory activity was evaluated.
Keywords: styrylquinoline derivatives; HIV-1 IN inhibitors; N-(styryl-8-hydroxyquinolin-7-yl)-benzenesulfonamide derivatives styrylquinoline derivatives; HIV-1 IN inhibitors; N-(styryl-8-hydroxyquinolin-7-yl)-benzenesulfonamide derivatives
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Jiao, Z.-G.; He, H.-Q.; Zeng, C.-C.; Tan, J.-J.; Hu, L.-M.; Wang, C.-X. Design, Synthesis and Anti-HIV Integrase Evaluation of N-(5-Chloro-8-Hydroxy-2-Styrylquinolin-7-yl)Benzenesulfonamide Derivatives. Molecules 2010, 15, 1903-1917.

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