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Molecules 2010, 15(3), 1903-1917; doi:10.3390/molecules15031903
Article

Design, Synthesis and Anti-HIV Integrase Evaluation of N-(5-Chloro-8-Hydroxy-2-Styrylquinolin-7-yl)Benzenesulfonamide Derivatives

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Received: 21 October 2009 / Revised: 8 December 2009 / Accepted: 14 December 2009 / Published: 16 March 2010
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Abstract

Styrylquinoline derivatives are demonstrated to be HIV-1 integrase inhibitors. On the basis of our previous CoMFA analysis of a series of styrylquinoline derivatives, N-[(2-substituted-styryl)-5-chloro-8-hydroxyquinolin-7-yl]-benzenesulfonamide derivatives were designed and synthesized,and their possible HIV IN inhibitory activity was evaluated.
Keywords: styrylquinoline derivatives; HIV-1 IN inhibitors; N-(styryl-8-hydroxyquinolin-7-yl)-benzenesulfonamide derivatives styrylquinoline derivatives; HIV-1 IN inhibitors; N-(styryl-8-hydroxyquinolin-7-yl)-benzenesulfonamide derivatives
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Jiao, Z.-G.; He, H.-Q.; Zeng, C.-C.; Tan, J.-J.; Hu, L.-M.; Wang, C.-X. Design, Synthesis and Anti-HIV Integrase Evaluation of N-(5-Chloro-8-Hydroxy-2-Styrylquinolin-7-yl)Benzenesulfonamide Derivatives. Molecules 2010, 15, 1903-1917.

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