Molecules 2010, 15(2), 857-870; doi:10.3390/molecules15020857
Article

Quercetin as a Potential Modulator of P-Glycoprotein Expression and Function in Cells of Human Pancreatic Carcinoma Line Resistant to Daunorubicin

1 Department of Histology and Embryology, Medical University, T. Chalubinski Street 6a, 50-368 Wroclaw, Poland 2 Department of Histology and Embryology, University of Medical Sciences in Poznan, Swiecickiego Street 6, 60-781 Poznan, Poland 3 Lower Silesian Centre of Oncology, Hirszfeld Square 12, 53-413 Wroclaw, Poland
* Author to whom correspondence should be addressed.
Received: 29 December 2009; in revised form: 28 January 2010 / Accepted: 3 February 2010 / Published: 9 February 2010
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Abstract: P-glycoprotein (P-gp) is one of the ABC transporters responsible for the resistance of several tumours to successful chemotherapy. Numerous agents are capable of interfering with the P-gp-mediated export of drugs but unfortunately most of them produce serious side effects. Some plant polyphenols, including the flavonol quercetin (Q), manifest anti-neoplastic activity mainly due to their influence on cell cycle control and apoptosis. Reports are also available which show that Q may intensify action of cytostatic drugs and suppress the multidrug resistance (MDR) phenomenon. The study aimed at determination if Q sensitizes cells resistant to daunorubicin (DB) through its effect on P-gp expression and action. The experiments were conducted on two cell lines of human pancreatic carcinoma, resistant to DB EPP85-181RDB and sensitive EPP85-181P as a comparison. Cells of both lines were exposed to selected concentrations of Q and DB, and then membranous expression of P-gp and its transport function were examined. The influence on expression of gene for P-gp (ABCB1) was also investigated. Results of the studies confirmed that Q affects expression and function of P-gp in a concentration-dependent manner. Moreover it decreased expression of ABCB1. Thus, Q may be considered as a potential modulator of P-gp.
Keywords: quercetin; daunorubicin; P-glycoprotein; multidrug resistance

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MDPI and ACS Style

Borska, S.; Sopel, M.; Chmielewska, M.; Zabel, M.; Dziegiel, P. Quercetin as a Potential Modulator of P-Glycoprotein Expression and Function in Cells of Human Pancreatic Carcinoma Line Resistant to Daunorubicin. Molecules 2010, 15, 857-870.

AMA Style

Borska S, Sopel M, Chmielewska M, Zabel M, Dziegiel P. Quercetin as a Potential Modulator of P-Glycoprotein Expression and Function in Cells of Human Pancreatic Carcinoma Line Resistant to Daunorubicin. Molecules. 2010; 15(2):857-870.

Chicago/Turabian Style

Borska, Sylwia; Sopel, Miroslaw; Chmielewska, Magdalena; Zabel, Maciej; Dziegiel, Piotr. 2010. "Quercetin as a Potential Modulator of P-Glycoprotein Expression and Function in Cells of Human Pancreatic Carcinoma Line Resistant to Daunorubicin." Molecules 15, no. 2: 857-870.

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