Molecules 2010, 15(2), 871-877; doi:10.3390/molecules15020871
Article

A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia Species

1,2email, 3, 1,4, 1, 5, 6, 1, 7,* email and 1,* email
Received: 16 December 2009; in revised form: 6 January 2010 / Accepted: 26 January 2010 / Published: 10 February 2010
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Abstract: A new 1,4-diazepine, callysponine (1), was isolated from a South China Sea Callyspongia sp. marine sponge, together with four known proline-based diketopiperazines: cyclo-(S-Pro-R-Leu) (2), cyclo-(S-Pro-R-Val) (3), cyclo-(S-Pro-R-Ala) (4), andcyclo-(S-Pro-R-Tyr) (5). The new structure was determined on the basis of NMR and MS analysis, and the absolute stereochemistry was defined by NOESY spectroscopy and optical rotation. The structures of the known compounds were identified by comparison of their spectroscopic data with those reported in the literature. Callysponine (1) did not inhibit the growth of HepG2 (hepatoma carcinoma cell), A549 (lung carcinoma cell), and HeLa (cervical cancer cell) cell lines.
Keywords: marine sponge; Callyspongia sp.; diazepine; callysponine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Huang, R.-M.; Ma, W.; Dong, J.-D.; Zhou, X.-F.; Xu, T.; Lee, K.J.; Yang, X.; Xu, S.-H.; Liu, Y. A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia Species. Molecules 2010, 15, 871-877.

AMA Style

Huang R-M, Ma W, Dong J-D, Zhou X-F, Xu T, Lee KJ, Yang X, Xu S-H, Liu Y. A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia Species. Molecules. 2010; 15(2):871-877.

Chicago/Turabian Style

Huang, Ri-Ming; Ma, Wei; Dong, Jun-De; Zhou, Xue-Feng; Xu, Tunhai; Lee, Kyung Jin; Yang, Xianwen; Xu, Shi-Hai; Liu, Yonghong. 2010. "A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia Species." Molecules 15, no. 2: 871-877.


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