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Molecules 2010, 15(2), 871-877; doi:10.3390/molecules15020871
Article

A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia Species

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3, 1,4, 1, 5, 6, 1, 7,*  and 1,*
Received: 16 December 2009 / Revised: 6 January 2010 / Accepted: 26 January 2010 / Published: 10 February 2010
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Abstract

A new 1,4-diazepine, callysponine (1), was isolated from a South China Sea Callyspongia sp. marine sponge, together with four known proline-based diketopiperazines: cyclo-(S-Pro-R-Leu) (2), cyclo-(S-Pro-R-Val) (3), cyclo-(S-Pro-R-Ala) (4), andcyclo-(S-Pro-R-Tyr) (5). The new structure was determined on the basis of NMR and MS analysis, and the absolute stereochemistry was defined by NOESY spectroscopy and optical rotation. The structures of the known compounds were identified by comparison of their spectroscopic data with those reported in the literature. Callysponine (1) did not inhibit the growth of HepG2 (hepatoma carcinoma cell), A549 (lung carcinoma cell), and HeLa (cervical cancer cell) cell lines.
Keywords: marine sponge; Callyspongia sp.; diazepine; callysponine marine sponge; Callyspongia sp.; diazepine; callysponine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Huang, R.-M.; Ma, W.; Dong, J.-D.; Zhou, X.-F.; Xu, T.; Lee, K.J.; Yang, X.; Xu, S.-H.; Liu, Y. A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia Species. Molecules 2010, 15, 871-877.

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