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A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia Species
AbstractA new 1,4-diazepine, callysponine (1), was isolated from a South China Sea Callyspongia sp. marine sponge, together with four known proline-based diketopiperazines: cyclo-(S-Pro-R-Leu) (2), cyclo-(S-Pro-R-Val) (3), cyclo-(S-Pro-R-Ala) (4), andcyclo-(S-Pro-R-Tyr) (5). The new structure was determined on the basis of NMR and MS analysis, and the absolute stereochemistry was defined by NOESY spectroscopy and optical rotation. The structures of the known compounds were identified by comparison of their spectroscopic data with those reported in the literature. Callysponine (1) did not inhibit the growth of HepG2 (hepatoma carcinoma cell), A549 (lung carcinoma cell), and HeLa (cervical cancer cell) cell lines.
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Huang, R.-M.; Ma, W.; Dong, J.-D.; Zhou, X.-F.; Xu, T.; Lee, K.J.; Yang, X.; Xu, S.-H.; Liu, Y. A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia Species. Molecules 2010, 15, 871-877.View more citation formats
Huang R-M, Ma W, Dong J-D, Zhou X-F, Xu T, Lee KJ, Yang X, Xu S-H, Liu Y. A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia Species. Molecules. 2010; 15(2):871-877.Chicago/Turabian Style
Huang, Ri-Ming; Ma, Wei; Dong, Jun-De; Zhou, Xue-Feng; Xu, Tunhai; Lee, Kyung Jin; Yang, Xianwen; Xu, Shi-Hai; Liu, Yonghong. 2010. "A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia Species." Molecules 15, no. 2: 871-877.
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