Next Article in Journal
Sesterterpenes and a New Sterol from the Marine Sponge Phyllospongia foliascens
Previous Article in Journal
Microwave-Assisted and Efficient Solvent-free Knoevenagel Condensation. A Sustainable Protocol Using Porous Calcium Hydroxyapatite as Catalyst
Molecules 2010, 15(2), 824-833; doi:10.3390/molecules15020824
Article

Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds

1
,
2
,
1
,
1
 and
1,*
Received: 22 January 2010 / Revised: 1 February 2010 / Accepted: 3 February 2010 / Published: 5 February 2010
Download PDF [174 KB, uploaded 18 June 2014]

Abstract

Ceramides play a crucial role in the barrier function of the skin as well as in transmembrane signaling. In this study long aliphatic chain tartaric acid diamides able to replace ceramides in an in vitro model of the stratum corneum lipid matrix due to their similar physico-chemical properties were synthesized from diacetoxysuccinic anhydride in four steps. Their pro-apoptotic effect on fibroblast cells was also investigated.
Keywords: ceramide-analogues; tartradiamides; transdermal penetration; apoptosis ceramide-analogues; tartradiamides; transdermal penetration; apoptosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Sinkó, B.; Pálfi, M.; Béni, S.; Kökösi, J.; Takács-Novák, K. Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds. Molecules 2010, 15, 824-833.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert