Molecules 2010, 15(2), 824-833; doi:10.3390/molecules15020824
Article

Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds

Bálint Sinkó 1 email, Melinda Pálfi 2 email, Szabolcs Béni 1 email, József Kökösi 1 email and Krisztina Takács-Novák 1,* email
1 Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes E.u.9., Budapest H-1092, Hungary 2 Department of Pharmacodynamics, Semmelweis University, Nagyvárad tér 4., Budapest H-1089, Hungary
* Author to whom correspondence should be addressed.
Received: 22 January 2010; in revised form: 1 February 2010 / Accepted: 3 February 2010 / Published: 5 February 2010
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Abstract: Ceramides play a crucial role in the barrier function of the skin as well as in transmembrane signaling. In this study long aliphatic chain tartaric acid diamides able to replace ceramides in an in vitro model of the stratum corneum lipid matrix due to their similar physico-chemical properties were synthesized from diacetoxysuccinic anhydride in four steps. Their pro-apoptotic effect on fibroblast cells was also investigated.
Keywords: ceramide-analogues; tartradiamides; transdermal penetration; apoptosis

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MDPI and ACS Style

Sinkó, B.; Pálfi, M.; Béni, S.; Kökösi, J.; Takács-Novák, K. Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds. Molecules 2010, 15, 824-833.

AMA Style

Sinkó B, Pálfi M, Béni S, Kökösi J, Takács-Novák K. Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds. Molecules. 2010; 15(2):824-833.

Chicago/Turabian Style

Sinkó, Bálint; Pálfi, Melinda; Béni, Szabolcs; Kökösi, József; Takács-Novák, Krisztina. 2010. "Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds." Molecules 15, no. 2: 824-833.

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