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Molecules 2010, 15(2), 660-671; doi:10.3390/molecules15020660

Antileishmanial, Antimicrobial and Antifungal Activities of Some New Aryl Azomethines

1
Institute of Biochemistry, University of Balochistan, Quetta, Pakistan
2
Synthetic Organic Chemistry Lab., Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt
*
Author to whom correspondence should be addressed.
Received: 5 December 2009 / Revised: 28 December 2009 / Accepted: 8 January 2010 / Published: 28 January 2010
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Abstract

A series of eighteen azomethines has been synthesized by the reaction of appropriate primary aromatic amines with aryl and/or heteroaryl carboxaldehydes. The synthesized azomethines have been evaluated for their in vitro antileishmanial, antibacterial and antifungal activities. The results revealed some antifungal activity of most of the synthesized compounds, whereas the antileishmaniasis activity results highlighted that all synthesized azomethines inhibited parasite growth and most of them showed highly potent action towards Leishmania major promastigotes. No remarkable bactericidal activities were observed.
Keywords: azomethines; primary aromatic amines; hetaryl carboxyladehyes; antileishmanial activity; antifungal activity; antibacterial activity azomethines; primary aromatic amines; hetaryl carboxyladehyes; antileishmanial activity; antifungal activity; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Al-Kahraman, Y.M.; Madkour, H.M.; Ali, D.; Yasinzai, M. Antileishmanial, Antimicrobial and Antifungal Activities of Some New Aryl Azomethines. Molecules 2010, 15, 660-671.

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