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Antileishmanial, Antimicrobial and Antifungal Activities of Some New Aryl Azomethines
Institute of Biochemistry, University of Balochistan, Quetta, Pakistan
Synthetic Organic Chemistry Lab., Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt
* Author to whom correspondence should be addressed.
Received: 5 December 2009; in revised form: 28 December 2009 / Accepted: 8 January 2010 / Published: 28 January 2010
Abstract: A series of eighteen azomethines has been synthesized by the reaction of appropriate primary aromatic amines with aryl and/or heteroaryl carboxaldehydes. The synthesized azomethines have been evaluated for their in vitro antileishmanial, antibacterial and antifungal activities. The results revealed some antifungal activity of most of the synthesized compounds, whereas the antileishmaniasis activity results highlighted that all synthesized azomethines inhibited parasite growth and most of them showed highly potent action towards Leishmania major promastigotes. No remarkable bactericidal activities were observed.
Keywords: azomethines; primary aromatic amines; hetaryl carboxyladehyes; antileishmanial activity; antifungal activity; antibacterial activity
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Al-Kahraman, Y.M.; Madkour, H.M.; Ali, D.; Yasinzai, M. Antileishmanial, Antimicrobial and Antifungal Activities of Some New Aryl Azomethines. Molecules 2010, 15, 660-671.
Al-Kahraman YM, Madkour HM, Ali D, Yasinzai M. Antileishmanial, Antimicrobial and Antifungal Activities of Some New Aryl Azomethines. Molecules. 2010; 15(2):660-671.
Al-Kahraman, Yasser M.S.A.; Madkour, Hassan. M.F.; Ali, Dildar; Yasinzai, Masoom. 2010. "Antileishmanial, Antimicrobial and Antifungal Activities of Some New Aryl Azomethines." Molecules 15, no. 2: 660-671.