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Molecules 2010, 15(12), 9340-9353; doi:10.3390/molecules15129340

Evaluation of the Bioactivity of Novel Spiroisoxazoline TypeCompounds against Normal and Cancer Cell Lines

1,* , 2
Received: 5 October 2010 / Revised: 3 November 2010 / Accepted: 2 December 2010 / Published: 17 December 2010
(This article belongs to the collection Bioactive Compounds)
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The aim of this study was to investigate the in vitro cellular activity of novel spiroisoxazoline type compounds against normal and cancer cell lines from lung tissue (Hs888Lu), neuron-phenotypic cells (SH-SY5Y), neuroblastoma (SH-SY5Y), human histiocytic lymphoma (U937), lung cancer (A549), and leukaemia (HL-60). Our bioassay program revealed that the spiroisoxazoline type compounds show cytotoxicity only in lymphoma cell lines, which is in contrast with the pyrrolidine precursor of these spiroisoxazoline compounds, where significant cytotoxicity is seen in all normal and cancer cell lines. These data suggest a tumour-specific mechanism of action. In addition these data also show that spiroisoxazoline compounds are non-toxic in the human neuronphenotypic neuroblastoma SH-SY5Y cell line, and furthermore that they might protect cells from neurodegenerative disease.
Keywords: pyrrolidine; spiroisoxazoline; cytotoxicity; neurotoxicity; neuroprotection pyrrolidine; spiroisoxazoline; cytotoxicity; neurotoxicity; neuroprotection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Najim, N.; Bathich, Y.; Zain, M.M.; Hamzah, A.S.; Shaameri, Z. Evaluation of the Bioactivity of Novel Spiroisoxazoline TypeCompounds against Normal and Cancer Cell Lines. Molecules 2010, 15, 9340-9353.

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