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Molecules 2010, 15(12), 9298-9307; doi:10.3390/molecules15129298

A Novel Benzo[f][1,7]Naphthyridine Produced by Streptomyces Albogriseolus from Mangrove Sediments

1,3,†, 2,†, 1 and 1,*
1 Key Laboratory of MOE for Microbial metabolism and School of Life Science & Biotechnology, State Key Laboratory of Ocean Engineering, Shanghai JiaoTong University, Shanghai 200240, China 2 Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China 3 Key Laboratory of Marine Biogenetic Resources, the Third Institute of Oceanography SOA, Xiamen, Fujian 361005, China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 24 October 2010 / Revised: 30 November 2010 / Accepted: 7 December 2010 / Published: 15 December 2010
(This article belongs to the Section Metabolites)
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Mangrove Streptomyces represent a rich source of novel bioactive compounds in medicinal research. A novel alkaloid, named 1-N-methyl-3-methylamino-[N-butanoic acid-3¢-(9¢-methyl-8¢-propen-7¢-one)-amide]-benzo[f][1,7]naphthyridine-2-one (1) was isolated from Streptomyces albogriseolus originating from mangrove sediments. The structure of compound 1 was elucidated by extensive spectroscopic data analyses and verified by the 13C-NMR calculation at the B3LYP/6-311+G(2d,p) level of theory.
Keywords: Streptomyces albogriseolus; mangrove; benzo[f][1,7]naphthyridine Streptomyces albogriseolus; mangrove; benzo[f][1,7]naphthyridine
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, X.-L.; Xu, M.-J.; Zhao, Y.-L.; Xu, J. A Novel Benzo[f][1,7]Naphthyridine Produced by Streptomyces Albogriseolus from Mangrove Sediments. Molecules 2010, 15, 9298-9307.

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