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Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease
Section of Plant Physiology and Biochemistry, Institute of Botany, Box 3005, 01061-970, São Paulo, SP, Brazil
Institute of Chemistry, São Paulo State University, Box 355, 14801-970, Araraquara, SP, Brazil
Department of Chemistry and Physics, São Paulo University, 14040-903, Ribeirão Preto, SP, Brazil
Department of Botany, Biosciences Institute, São Paulo University, Box 11.461, 05422-970, São, Paulo, SP, Brazil
* Author to whom correspondence should be addressed.
Received: 15 November 2010; in revised form: 2 December 2010 / Accepted: 6 December 2010 / Published: 13 December 2010
Abstract: Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guarantã, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid leptomerine showed the highest activity (IC50 = 2.5 mM), similar to that of the reference compound galanthamine (IC50 = 1.7 mM). The results showed for the first time the presence of alkaloids leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity.
Keywords: Esenbeckia leiocarpa; Rutaceae; alkaloids; acetylcholinesterase inhibitors
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Cardoso-Lopes, E.M.; Maier, J.A.; Silva, M.R.; Regasini, L.O.; Simote, S.Y.; Lopes, N.P.; Pirani, J.R.; Bolzani, V.S.; Young, M.C.M. Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease. Molecules 2010, 15, 9205-9213.
Cardoso-Lopes EM, Maier JA, Silva MR, Regasini LO, Simote SY, Lopes NP, Pirani JR, Bolzani VS, Young MCM. Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease. Molecules. 2010; 15(12):9205-9213.
Cardoso-Lopes, Elaine Monteiro; Maier, James Andreas; Silva, Marcelo Rogério da; Regasini, Luis Octávio; Simote, Simone Yasue; Lopes, Norberto Peporine; Pirani, José Rubens; Bolzani, Vanderlan da Silva; Young, Maria Cláudia Marx. 2010. "Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease." Molecules 15, no. 12: 9205-9213.