Molecules 2010, 15(12), 8827-8840; doi:10.3390/molecules15128827
Article

Microwave Assisted Synthesis of Some New Heterocyclic Spiro-Derivatives with Potential Antimicrobial and Antioxidant Activity

1,†,* email and 2,†
Received: 31 October 2010; in revised form: 17 November 2010 / Accepted: 30 November 2010 / Published: 3 December 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Homophthalic anhydride reacts with different aromatic amines to produce N-substituted homophthalimides. Bromination of the latter produces 4,4-dibromo-homophthalimide derivatives that can be used as precursors for spiro-derivatives. The dibromo derivatives react with different binucleophilic reagents to produce several spiro-isoquinoline derivatives. Reaction of the dibromo derivatives with malononitrile produces dicyanomethylene derivatives which react with different binucleophiles to produce new spiro-derivatives. Structures of the newly synthesized compounds are proved using spectroscopic methods such as IR, 1H-NMR and 13C-NMR. The newly synthesized compounds were tested for their antimicrobial and antioxidant activities, showing weak or no antimicrobial activity. On the other hand select compounds showed promising antioxidant activities.
Keywords: microwave; spiro-compounds; heterocycles; spiro-benzoxazoleisoquinoline; spiro-benzimidazoleisoquinoline; spiro-isoquinolinetriazole; spiro-isoquinolinepyrazole; spiro-isoquinolinepyrimidine; antimicrobial activity; antioxidant activity
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MDPI and ACS Style

Youssef, M.M.; Amin, M.A. Microwave Assisted Synthesis of Some New Heterocyclic Spiro-Derivatives with Potential Antimicrobial and Antioxidant Activity. Molecules 2010, 15, 8827-8840.

AMA Style

Youssef MM, Amin MA. Microwave Assisted Synthesis of Some New Heterocyclic Spiro-Derivatives with Potential Antimicrobial and Antioxidant Activity. Molecules. 2010; 15(12):8827-8840.

Chicago/Turabian Style

Youssef, Mohamed Mohamed; Amin, Mahmoud Ahmed. 2010. "Microwave Assisted Synthesis of Some New Heterocyclic Spiro-Derivatives with Potential Antimicrobial and Antioxidant Activity." Molecules 15, no. 12: 8827-8840.


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