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Molecules 2010, 15(12), 8827-8840; doi:10.3390/molecules15128827
Article

Microwave Assisted Synthesis of Some New Heterocyclic Spiro-Derivatives with Potential Antimicrobial and Antioxidant Activity

1,†,*  and 2,†
1 Chemistry Department, Faculty of Science, Cairo University, Egypt 2 Chemistry Department, Faculty of Science, Suez Canal University, Egypt Current Address: Chemistry Department, Faculty of Science, Taif University, Saudi Arabia.
* Author to whom correspondence should be addressed.
Received: 31 October 2010 / Revised: 17 November 2010 / Accepted: 30 November 2010 / Published: 3 December 2010
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Abstract

Homophthalic anhydride reacts with different aromatic amines to produce N-substituted homophthalimides. Bromination of the latter produces 4,4-dibromo-homophthalimide derivatives that can be used as precursors for spiro-derivatives. The dibromo derivatives react with different binucleophilic reagents to produce several spiro-isoquinoline derivatives. Reaction of the dibromo derivatives with malononitrile produces dicyanomethylene derivatives which react with different binucleophiles to produce new spiro-derivatives. Structures of the newly synthesized compounds are proved using spectroscopic methods such as IR, 1H-NMR and 13C-NMR. The newly synthesized compounds were tested for their antimicrobial and antioxidant activities, showing weak or no antimicrobial activity. On the other hand select compounds showed promising antioxidant activities.
Keywords: microwave; spiro-compounds; heterocycles; spiro-benzoxazoleisoquinoline; spiro-benzimidazoleisoquinoline; spiro-isoquinolinetriazole; spiro-isoquinolinepyrazole; spiro-isoquinolinepyrimidine; antimicrobial activity; antioxidant activity microwave; spiro-compounds; heterocycles; spiro-benzoxazoleisoquinoline; spiro-benzimidazoleisoquinoline; spiro-isoquinolinetriazole; spiro-isoquinolinepyrazole; spiro-isoquinolinepyrimidine; antimicrobial activity; antioxidant activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Youssef, M.M.; Amin, M.A. Microwave Assisted Synthesis of Some New Heterocyclic Spiro-Derivatives with Potential Antimicrobial and Antioxidant Activity. Molecules 2010, 15, 8827-8840.

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