Next Article in Journal
Platycoside N: A New Oleanane-Type Triterpenoid Saponin from the Roots of Platycodon grandiflorum
Previous Article in Journal
Supramolecular Self-Assembled Chaos: Polyphenolic Lignin’s Barrier to Cost-Effective Lignocellulosic Biofuels
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2010, 15(12), 8689-8701; https://doi.org/10.3390/molecules15128689

Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
*
Author to whom correspondence should be addressed.
Received: 6 November 2010 / Revised: 17 November 2010 / Accepted: 22 November 2010 / Published: 30 November 2010
Download PDF [225 KB, uploaded 18 June 2014]

Abstract

A novel trifluoromethylated analogue of cADPR, 8-CF3-cIDPDE (5) was designed and synthesized via construction of N1,N9-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds could be useful molecules for studying the structure-activity relationship of cADPR analogues and exploring the cADPR/RyR Ca2+ signalling system.
Keywords: cADPR analogue; acyclic cADPR analogue; trifluoromethylation; synthesis cADPR analogue; acyclic cADPR analogue; trifluoromethylation; synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Huang, X.; Dong, M.; Liu, J.; Zhang, K.; Yang, Z.; Zhang, L.; Zhang, L. Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR. Molecules 2010, 15, 8689-8701.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top