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Molecules 2010, 15(12), 8689-8701; doi:10.3390/molecules15128689
Article

Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR

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Received: 6 November 2010; in revised form: 17 November 2010 / Accepted: 22 November 2010 / Published: 30 November 2010
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Abstract: A novel trifluoromethylated analogue of cADPR, 8-CF3-cIDPDE (5) was designed and synthesized via construction of N1,N9-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds could be useful molecules for studying the structure-activity relationship of cADPR analogues and exploring the cADPR/RyR Ca2+ signalling system.
Keywords: cADPR analogue; acyclic cADPR analogue; trifluoromethylation; synthesis cADPR analogue; acyclic cADPR analogue; trifluoromethylation; synthesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Huang, X.; Dong, M.; Liu, J.; Zhang, K.; Yang, Z.; Zhang, L.; Zhang, L. Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR. Molecules 2010, 15, 8689-8701.

AMA Style

Huang X, Dong M, Liu J, Zhang K, Yang Z, Zhang L, Zhang L. Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR. Molecules. 2010; 15(12):8689-8701.

Chicago/Turabian Style

Huang, Xiangchen; Dong, Min; Liu, Jian; Zhang, Kehui; Yang, Zhenjun; Zhang, Liangren; Zhang, Lihe. 2010. "Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR." Molecules 15, no. 12: 8689-8701.


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