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Molecules 2010, 15(12), 8702-8708; doi:10.3390/molecules15128702

Platycoside N: A New Oleanane-Type Triterpenoid Saponin from the Roots of Platycodon grandiflorum

1,†, 1,†, 2, 1, 1,* , 3,* , 1 and 4
1 College of Chinese Material Medicine, Jilin Agricultural University, Changchun 130118, China 2 School of Pharmacy, Shangdong University, Jinan 250012, China 3 Institute of Special Wild Economic Animals and Plant, CAAS, Jilin 132109, China 4 Norman Bethune College of Medicine, Jilin University, Changchun 130021, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 13 September 2010 / Revised: 22 November 2010 / Accepted: 25 November 2010 / Published: 30 November 2010
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A new oleanane-type triterpenoid saponin, named platycoside N (1), together with six known saponins, was isolated from the roots of Platycodon grandiflorum. On the basis of acid hydrolysis, comprehensive spectroscopic data analyses and comparison with the spectral data of the known compounds, its structure was elucidated as 3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl-2β,3β,16α,23-tetrahydroxyolean-12-en-28-oic acid 28-O-β-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside. The six known compounds were platycodin D (2), deapioplatycodin D (3), platycodin D3 (4), deapio- platycodin D3 (5), platycoside E (6) and deapioplatycoside E (7).
Keywords: platycoside N; Platycodon grandiflorum; triterpenoid saponin platycoside N; Platycodon grandiflorum; triterpenoid saponin
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Li, W.; Zhang, W.; Xiang, L.; Wang, Z.; Zheng, Y.-N.; Wang, Y.-P.; Zhang, J.; Chen, L. Platycoside N: A New Oleanane-Type Triterpenoid Saponin from the Roots of Platycodon grandiflorum. Molecules 2010, 15, 8702-8708.

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