A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis

doi:10.3390/molecules15118360

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Molecules 2010, 15(11), 8360-8365; doi:10.3390/molecules15118360

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A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis

Xiang-Zhong Huang¹, Chun-Mei Cheng¹, Yun Dai¹, Guang-Miao Fu^2,* , Jun-Ming Guo¹, Yan Yin¹ and Hui Liang¹

¹ Key Laboratory of Ethnic Medicine Resource Chemistry, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650031, China ² School of Pharmacy, Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China

* Author to whom correspondence should be addressed.

Received: 10 September 2010; in revised form: 4 November 2010 / Accepted: 10 November 2010 / Published: 16 November 2010

(This article belongs to the Section Natural Products)

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Abstract: A novel 18-nor-clerodane diterpenoid named sagitone (1) was isolated from the 95% ethanol extract of dry roots of Tinospora sagittata var. yunnanensis together with the five known diterpenoids columbin (2), palmatoside C (3), fibleucin (4), tinophylloloside (5) and epitinophylloloside (6). The structure of the new compound 1 was determined based on MS, IR, 1D and 2D NMR spectral data. The compounds 1~6 did not show significant cytotoxic activity against cancer cell lines K562 and HL-60.

Keywords: Tinospora sagittata var. Yunnanensis; clerodane diterpenoid; sagitone; cytotoxic activity

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Cite This Article

MDPI and ACS Style

Huang, X.-Z.; Cheng, C.-M.; Dai, Y.; Fu, G.-M.; Guo, J.-M.; Yin, Y.; Liang, H. A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis. Molecules 2010, 15, 8360-8365.

AMA Style

Huang X-Z, Cheng C-M, Dai Y, Fu G-M, Guo J-M, Yin Y, Liang H. A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis. Molecules. 2010; 15(11):8360-8365.

Chicago/Turabian Style

Huang, Xiang-Zhong; Cheng, Chun-Mei; Dai, Yun; Fu, Guang-Miao; Guo, Jun-Ming; Yin, Yan; Liang, Hui. 2010. "A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis." Molecules 15, no. 11: 8360-8365.

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