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Molecules 2010, 15(11), 8360-8365; doi:10.3390/molecules15118360
Article

A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis

1, 1, 1, 2,* , 1, 1 and 1
1 Key Laboratory of Ethnic Medicine Resource Chemistry, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650031, China 2 School of Pharmacy, Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China
* Author to whom correspondence should be addressed.
Received: 10 September 2010 / Revised: 4 November 2010 / Accepted: 10 November 2010 / Published: 16 November 2010
(This article belongs to the Section Natural Products)
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Abstract

A novel 18-nor-clerodane diterpenoid named sagitone (1) was isolated from the 95% ethanol extract of dry roots of Tinospora sagittata var. yunnanensis together with the five known diterpenoids columbin (2), palmatoside C (3), fibleucin (4), tinophylloloside (5) and epitinophylloloside (6). The structure of the new compound 1 was determined based on MS, IR, 1D and 2D NMR spectral data. The compounds 1~6 did not show significant cytotoxic activity against cancer cell lines K562 and HL-60.
Keywords: Tinospora sagittata var. Yunnanensis; clerodane diterpenoid; sagitone; cytotoxic activity Tinospora sagittata var. Yunnanensis; clerodane diterpenoid; sagitone; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Huang, X.-Z.; Cheng, C.-M.; Dai, Y.; Fu, G.-M.; Guo, J.-M.; Yin, Y.; Liang, H. A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis. Molecules 2010, 15, 8360-8365.

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