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Molecules 2010, 15(11), 8360-8365; doi:10.3390/molecules15118360
Article

A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis

1, 1, 1, 2,* , 1, 1 and 1
1 Key Laboratory of Ethnic Medicine Resource Chemistry, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650031, China 2 School of Pharmacy, Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China
* Author to whom correspondence should be addressed.
Received: 10 September 2010 / Revised: 4 November 2010 / Accepted: 10 November 2010 / Published: 16 November 2010
(This article belongs to the Section Metabolites)
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Abstract

A novel 18-nor-clerodane diterpenoid named sagitone (1) was isolated from the 95% ethanol extract of dry roots of Tinospora sagittata var. yunnanensis together with the five known diterpenoids columbin (2), palmatoside C (3), fibleucin (4), tinophylloloside (5) and epitinophylloloside (6). The structure of the new compound 1 was determined based on MS, IR, 1D and 2D NMR spectral data. The compounds 1~6 did not show significant cytotoxic activity against cancer cell lines K562 and HL-60.
Keywords: Tinospora sagittata var. Yunnanensis; clerodane diterpenoid; sagitone; cytotoxic activity Tinospora sagittata var. Yunnanensis; clerodane diterpenoid; sagitone; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Huang, X.-Z.; Cheng, C.-M.; Dai, Y.; Fu, G.-M.; Guo, J.-M.; Yin, Y.; Liang, H. A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis. Molecules 2010, 15, 8360-8365.

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