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A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis
Key Laboratory of Ethnic Medicine Resource Chemistry, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650031, China
School of Pharmacy, Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China
* Author to whom correspondence should be addressed.
Received: 10 September 2010; in revised form: 4 November 2010 / Accepted: 10 November 2010 / Published: 16 November 2010
Abstract: A novel 18-nor-clerodane diterpenoid named sagitone (1) was isolated from the 95% ethanol extract of dry roots of Tinospora sagittata var. yunnanensis together with the five known diterpenoids columbin (2), palmatoside C (3), fibleucin (4), tinophylloloside (5) and epitinophylloloside (6). The structure of the new compound 1 was determined based on MS, IR, 1D and 2D NMR spectral data. The compounds 1~6 did not show significant cytotoxic activity against cancer cell lines K562 and HL-60.
Keywords: Tinospora sagittata var. Yunnanensis; clerodane diterpenoid; sagitone; cytotoxic activity
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Huang, X.-Z.; Cheng, C.-M.; Dai, Y.; Fu, G.-M.; Guo, J.-M.; Yin, Y.; Liang, H. A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis. Molecules 2010, 15, 8360-8365.
Huang X-Z, Cheng C-M, Dai Y, Fu G-M, Guo J-M, Yin Y, Liang H. A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis. Molecules. 2010; 15(11):8360-8365.
Huang, Xiang-Zhong; Cheng, Chun-Mei; Dai, Yun; Fu, Guang-Miao; Guo, Jun-Ming; Yin, Yan; Liang, Hui. 2010. "A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis." Molecules 15, no. 11: 8360-8365.