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Molecules 2010, 15(11), 8251-8259; doi:10.3390/molecules15118251

Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides

1 Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Institute (KAERI), Jeongeup 580-185, Korea 2 Department of Applied Life Sciences, Chonbuk National University, Jeonju 561-756, Korea 3 Senior Industry Cluster Agency, Youngdong University, Youngdong 370-701, Korea 4 Department of Herbal Medicinal Pharmacology, Daegu Haany University, Gyeongsan 712-715, Korea
* Author to whom correspondence should be addressed.
Received: 2 November 2010 / Revised: 11 November 2010 / Accepted: 12 November 2010 / Published: 16 November 2010
(This article belongs to the collection Bioactive Compounds)
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Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-b-D-boivinopyranoside (1), as well as eight known compounds. The structures of these compounds were established on the basis of interpretation of their spectroscopic data. Among these isolates, the C-glycosidic flavones 15 showed potent inhibitory effects on pancreatic lipase, with IC50 values ranging from 18.5 ± 2.6 to 50.5 ± 3.9 mM.
Keywords: Eremochloa ophiuroides; C-glycosidic flavones; obesity; pancreatic lipase Eremochloa ophiuroides; C-glycosidic flavones; obesity; pancreatic lipase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lee, E.M.; Lee, S.S.; Chung, B.Y.; Cho, J.-Y.; Lee, I.C.; Ahn, S.R.; Jang, S.J.; Kim, T.H. Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides. Molecules 2010, 15, 8251-8259.

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