Molecules 2010, 15(11), 8251-8259; doi:10.3390/molecules15118251
Article

Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides

1 Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Institute (KAERI), Jeongeup 580-185, Korea 2 Department of Applied Life Sciences, Chonbuk National University, Jeonju 561-756, Korea 3 Senior Industry Cluster Agency, Youngdong University, Youngdong 370-701, Korea 4 Department of Herbal Medicinal Pharmacology, Daegu Haany University, Gyeongsan 712-715, Korea
* Author to whom correspondence should be addressed.
Received: 2 November 2010; in revised form: 11 November 2010 / Accepted: 12 November 2010 / Published: 16 November 2010
(This article belongs to the collection Bioactive Compounds)
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Abstract: Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-b-D-boivinopyranoside (1), as well as eight known compounds. The structures of these compounds were established on the basis of interpretation of their spectroscopic data. Among these isolates, the C-glycosidic flavones 15 showed potent inhibitory effects on pancreatic lipase, with IC50 values ranging from 18.5 ± 2.6 to 50.5 ± 3.9 mM.
Keywords: Eremochloa ophiuroides; C-glycosidic flavones; obesity; pancreatic lipase

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MDPI and ACS Style

Lee, E.M.; Lee, S.S.; Chung, B.Y.; Cho, J.-Y.; Lee, I.C.; Ahn, S.R.; Jang, S.J.; Kim, T.H. Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides. Molecules 2010, 15, 8251-8259.

AMA Style

Lee EM, Lee SS, Chung BY, Cho J-Y, Lee IC, Ahn SR, Jang SJ, Kim TH. Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides. Molecules. 2010; 15(11):8251-8259.

Chicago/Turabian Style

Lee, Eun Mi; Lee, Seung Sik; Chung, Byung Yeoup; Cho, Jae-Young; Lee, In Chul; Ahn, So Ra; Jang, Soo Jeung; Kim, Tae Hoon. 2010. "Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides." Molecules 15, no. 11: 8251-8259.

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