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Molecules 2010, 15(11), 8251-8259; https://doi.org/10.3390/molecules15118251

Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides

1
Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Institute (KAERI), Jeongeup 580-185, Korea
2
Department of Applied Life Sciences, Chonbuk National University, Jeonju 561-756, Korea
3
Senior Industry Cluster Agency, Youngdong University, Youngdong 370-701, Korea
4
Department of Herbal Medicinal Pharmacology, Daegu Haany University, Gyeongsan 712-715, Korea
*
Author to whom correspondence should be addressed.
Received: 2 November 2010 / Revised: 11 November 2010 / Accepted: 12 November 2010 / Published: 16 November 2010
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-b-D-boivinopyranoside (1), as well as eight known compounds. The structures of these compounds were established on the basis of interpretation of their spectroscopic data. Among these isolates, the C-glycosidic flavones 15 showed potent inhibitory effects on pancreatic lipase, with IC50 values ranging from 18.5 ± 2.6 to 50.5 ± 3.9 mM.
Keywords: Eremochloa ophiuroides; C-glycosidic flavones; obesity; pancreatic lipase Eremochloa ophiuroides; C-glycosidic flavones; obesity; pancreatic lipase
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lee, E.M.; Lee, S.S.; Chung, B.Y.; Cho, J.-Y.; Lee, I.C.; Ahn, S.R.; Jang, S.J.; Kim, T.H. Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides. Molecules 2010, 15, 8251-8259.

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