Abstract: Peptides selected from phage-displayed random peptide libraries are valuable in two aspects. On one hand, these peptides are candidates for new diagnostics, therapeutics and vaccines. On the other hand, they can be used to predict the networks or sites of protein-protein interactions. MimoDB, a new repository for these peptides, was developed, in which 10,716 peptides collected from 571 publications were grouped into 1,229 sets. Besides peptide sequences, other important information, such as the target, template, library and complex structure, was also included. MimoDB can be browsed and searched through a user-friendly web interface. For computational biologists, MimoDB can be used to derive customized data sets and benchmarks, which are useful for new algorithm development and tool evaluation. For experimental biologists, their results can be searched against the MimoDB database to exclude possible target-unrelated peptides. The MimoDB database is freely accessible at http://immunet.cn/mimodb/.
Keywords: mimotope; phage display; biopanning; combinatorial libraries; target-unrelated peptides
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Ru, B.; Huang, J.; Dai, P.; Li, S.; Xia, Z.; Ding, H.; Lin, H.; Guo, F.-B.; Wang, X. MimoDB: a New Repository for Mimotope Data Derived from Phage Display Technology. Molecules 2010, 15, 8279-8288.
Ru B, Huang J, Dai P, Li S, Xia Z, Ding H, Lin H, Guo F-B, Wang X. MimoDB: a New Repository for Mimotope Data Derived from Phage Display Technology. Molecules. 2010; 15(11):8279-8288.
Ru, Beibei; Huang, Jian; Dai, Ping; Li, Shiyong; Xia, Zhongkui; Ding, Hui; Lin, Hao; Guo, Feng-Biao; Wang, Xianlong. 2010. "MimoDB: a New Repository for Mimotope Data Derived from Phage Display Technology." Molecules 15, no. 11: 8279-8288.