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Molecules 2010, 15(11), 7923-7932; doi:10.3390/molecules15117923

Optimizing Ultrasonic Ellagic Acid Extraction Conditions from Infructescence of Platycarya strobilacea Using Response Surface Methodology

1
Institute of Chemical Industry of Forest Products, CAF, National Engineering Lab. for Biomass Chemical Utilization, Key and Open Lab. on Forest Chemical Engineering, SFA, Key Lab. of Biomass Energy and Material, Nanjing 210042, China
2
Institute of New Technology of Forestry, CAF, Beijing 100091, China
*
Author to whom correspondence should be addressed.
Received: 30 September 2010 / Revised: 1 October 2010 / Accepted: 3 November 2010 / Published: 4 November 2010
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Abstract

The infructescence of Platycarya strobilacea is a rich source of ellagic acid (EA) which has shown antioxidant, anticancer and antimutagen properties. Response surface methodology (RSM) was used to optimize the conditions for ultrasonic extraction of EA from infructescence of P. strobilacea. A central composite design (CCD) was used for experimental design and analysis of the results to obtain the optimal processing parameters. The content of EA in the extracts was determined by HPLC with UV detection. Three independent variables such as ultrasonic extraction temperature (°C), liquid:solid ratio (mL/g), and ultrasonic extraction time (min) were investigated. The experimental data obtained were fitted to a quadratic equation using multiple regression analysis and also analyzed by appropriate statistical methods. The 3-D response surface and the contour plots derived from the mathematical models were applied to determine the optimal conditions. The optimum ultrasonic extraction conditions were as follows: ultrasonic extraction temperature 70 °C, liquid:solid ratio 22.5, and ultrasonic extraction time 40 min. Under these conditions, the experimental percentage value was 1.961%, which is in close agreement with the value predicted by the model.
Keywords: Platycarya strobilacea; ellagic acid; ultrasonic extraction; optimization; response surface methodology Platycarya strobilacea; ellagic acid; ultrasonic extraction; optimization; response surface methodology
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MDPI and ACS Style

Zhang, L.-L.; Xu, M.; Wang, Y.-M.; Wu, D.-M.; Chen, J.-H. Optimizing Ultrasonic Ellagic Acid Extraction Conditions from Infructescence of Platycarya strobilacea Using Response Surface Methodology. Molecules 2010, 15, 7923-7932.

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