Molecules 2010, 15(11), 7840-7848; doi:10.3390/molecules15117840
Article

Inhibitory Effects of Phylligenin and Quebrachitol Isolated from Mitrephora vulpina on Platelet Activating Factor Receptor Binding and Platelet Aggregation

Bushra Abdulkarim Moharam 1 , Ibrahim Jantan 1,* email, Juriyati Jalil 1  and Khozirah Shaari 2
1 Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia 2 Institute of Bioscience, Universiti Putra Malaysia 43400 Serdang, Selangor, Malaysia
* Author to whom correspondence should be addressed.
Received: 20 September 2010; in revised form: 15 October 2010 / Accepted: 25 October 2010 / Published: 3 November 2010
(This article belongs to the Section Natural Products)
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Abstract: Phylligenine, together with quebrachitol, stigmasterol and two aporphine alkaloids—oxoputerine and liriodenine—were isolated from the twigs of Mitrephora vulpina C.E.C. Fisch. They were evaluated for their ability to inhibit platelet activating factor (PAF) receptor binding to rabbit platelets using 3H-PAF as a ligand and their antiplatelet aggregation effect in human whole blood induced by arachidonic acid (AA), collagen and adenosine diphosphate (ADP). Of all the compounds tested, phylligenin and quebrachitol exhibited potent and concentration-dependent inhibitory effects on PAF receptor binding, with IC50 values of 13.1 and 42.2 µM, respectively. The IC50 value of phylligenin was comparable to that of cedrol (10.2 µM), a potent PAF antagonist. Phylligenin also showed strong dose-dependent inhibitory activity on platelet aggregation induced by AA and ADP.
Keywords: Mitrephora vulpina; phylligenin; quebrachitol; platelet activating factor (PAF) antagonist; antiplatelet activity

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MDPI and ACS Style

Moharam, B.A.; Jantan, I.; Jalil, J.; Shaari, K. Inhibitory Effects of Phylligenin and Quebrachitol Isolated from Mitrephora vulpina on Platelet Activating Factor Receptor Binding and Platelet Aggregation. Molecules 2010, 15, 7840-7848.

AMA Style

Moharam BA, Jantan I, Jalil J, Shaari K. Inhibitory Effects of Phylligenin and Quebrachitol Isolated from Mitrephora vulpina on Platelet Activating Factor Receptor Binding and Platelet Aggregation. Molecules. 2010; 15(11):7840-7848.

Chicago/Turabian Style

Moharam, Bushra Abdulkarim; Jantan, Ibrahim; Jalil, Juriyati; Shaari, Khozirah. 2010. "Inhibitory Effects of Phylligenin and Quebrachitol Isolated from Mitrephora vulpina on Platelet Activating Factor Receptor Binding and Platelet Aggregation." Molecules 15, no. 11: 7840-7848.

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