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Correction published on 24 March 2014, see Molecules 2014, 19(3), 3848-3849.

Open AccessArticle
Molecules 2010, 15(11), 7840-7848; doi:10.3390/molecules15117840

Inhibitory Effects of Phylligenin and Quebrachitol Isolated from Mitrephora vulpina on Platelet Activating Factor Receptor Binding and Platelet Aggregation

1
Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
2
Institute of Bioscience, Universiti Putra Malaysia 43400 Serdang, Selangor, Malaysia
*
Author to whom correspondence should be addressed.
Received: 20 September 2010 / Revised: 15 October 2010 / Accepted: 25 October 2010 / Published: 3 November 2010
(This article belongs to the Section Natural Products)
Download PDF [173 KB, 18 June 2014; original version 18 June 2014]

Abstract

Phylligenine, together with quebrachitol, stigmasterol and two aporphine alkaloids—oxoputerine and liriodenine—were isolated from the twigs of Mitrephora vulpina C.E.C. Fisch. They were evaluated for their ability to inhibit platelet activating factor (PAF) receptor binding to rabbit platelets using 3H-PAF as a ligand and their antiplatelet aggregation effect in human whole blood induced by arachidonic acid (AA), collagen and adenosine diphosphate (ADP). Of all the compounds tested, phylligenin and quebrachitol exhibited potent and concentration-dependent inhibitory effects on PAF receptor binding, with IC50 values of 13.1 and 42.2 µM, respectively. The IC50 value of phylligenin was comparable to that of cedrol (10.2 µM), a potent PAF antagonist. Phylligenin also showed strong dose-dependent inhibitory activity on platelet aggregation induced by AA and ADP.
Keywords: Mitrephora vulpina; phylligenin; quebrachitol; platelet activating factor (PAF) antagonist; antiplatelet activity Mitrephora vulpina; phylligenin; quebrachitol; platelet activating factor (PAF) antagonist; antiplatelet activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

  • Correction

    Correction (PDF, 191 KB)

    The authors wish to inform readers that there are several minor errors and omissions in the chemical structures shown in Figure 1 of this paper [1].

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MDPI and ACS Style

Moharam, B.A.; Jantan, I.; Jalil, J.; Shaari, K. Inhibitory Effects of Phylligenin and Quebrachitol Isolated from Mitrephora vulpina on Platelet Activating Factor Receptor Binding and Platelet Aggregation. Molecules 2010, 15, 7840-7848.

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