Next Article in Journal
Previous Article in Journal
A correction was published on 24 March 2014, see Molecules 2014, 19(3), 3848-3849.

Molecules 2010, 15(11), 7840-7848; doi:10.3390/molecules15117840
Article

Inhibitory Effects of Phylligenin and Quebrachitol Isolated from Mitrephora vulpina on Platelet Activating Factor Receptor Binding and Platelet Aggregation

1, 1,* , 1 and 2
Received: 20 September 2010; in revised form: 15 October 2010 / Accepted: 25 October 2010 / Published: 3 November 2010
(This article belongs to the Section Metabolites)
Download PDF [173 KB, updated 18 June 2014; original version uploaded 18 June 2014]
Abstract: Phylligenine, together with quebrachitol, stigmasterol and two aporphine alkaloids—oxoputerine and liriodenine—were isolated from the twigs of Mitrephora vulpina C.E.C. Fisch. They were evaluated for their ability to inhibit platelet activating factor (PAF) receptor binding to rabbit platelets using 3H-PAF as a ligand and their antiplatelet aggregation effect in human whole blood induced by arachidonic acid (AA), collagen and adenosine diphosphate (ADP). Of all the compounds tested, phylligenin and quebrachitol exhibited potent and concentration-dependent inhibitory effects on PAF receptor binding, with IC50 values of 13.1 and 42.2 µM, respectively. The IC50 value of phylligenin was comparable to that of cedrol (10.2 µM), a potent PAF antagonist. Phylligenin also showed strong dose-dependent inhibitory activity on platelet aggregation induced by AA and ADP.
Keywords: Mitrephora vulpina; phylligenin; quebrachitol; platelet activating factor (PAF) antagonist; antiplatelet activity Mitrephora vulpina; phylligenin; quebrachitol; platelet activating factor (PAF) antagonist; antiplatelet activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • Correction

    Correction (PDF, 191 KB)

    The authors wish to inform readers that there are several minor errors and omissions in the chemical structures shown in Figure 1 of this paper [1].

Export to BibTeX |
EndNote


MDPI and ACS Style

Moharam, B.A.; Jantan, I.; Jalil, J.; Shaari, K. Inhibitory Effects of Phylligenin and Quebrachitol Isolated from Mitrephora vulpina on Platelet Activating Factor Receptor Binding and Platelet Aggregation. Molecules 2010, 15, 7840-7848.

AMA Style

Moharam BA, Jantan I, Jalil J, Shaari K. Inhibitory Effects of Phylligenin and Quebrachitol Isolated from Mitrephora vulpina on Platelet Activating Factor Receptor Binding and Platelet Aggregation. Molecules. 2010; 15(11):7840-7848.

Chicago/Turabian Style

Moharam, Bushra Abdulkarim; Jantan, Ibrahim; Jalil, Juriyati; Shaari, Khozirah. 2010. "Inhibitory Effects of Phylligenin and Quebrachitol Isolated from Mitrephora vulpina on Platelet Activating Factor Receptor Binding and Platelet Aggregation." Molecules 15, no. 11: 7840-7848.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert