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Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties
Four Tigers LLC, 1501 Bull Lea Road, Suite 105, Lexington, Kentucky 40511 USA
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA
Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
* Author to whom correspondence should be addressed.
Received: 10 September 2010; in revised form: 15 October 2010 / Accepted: 19 October 2010 / Published: 21 October 2010
Abstract: Phenolics are broadly distributed in the plant kingdom and are the most abundant secondary metabolites of plants. Plant polyphenols have drawn increasing attention due to their potent antioxidant properties and their marked effects in the prevention of various oxidative stress associated diseases such as cancer. In the last few years, the identification and development of phenolic compounds or extracts from different plants has become a major area of health- and medical-related research. This review provides an updated and comprehensive overview on phenolic extraction, purification, analysis and quantification as well as their antioxidant properties. Furthermore, the anticancer effects of phenolics in-vitro and in-vivo animal models are viewed, including recent human intervention studies. Finally, possible mechanisms of action involving antioxidant and pro-oxidant activity as well as interference with cellular functions are discussed.
Keywords: plant phenolics; extraction; analysis; antioxidant; anticancer
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MDPI and ACS Style
Dai, J.; Mumper, R.J. Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties. Molecules 2010, 15, 7313-7352.
Dai J, Mumper RJ. Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties. Molecules. 2010; 15(10):7313-7352.
Dai, Jin; Mumper, Russell J. 2010. "Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties." Molecules 15, no. 10: 7313-7352.