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Molecules 2010, 15(10), 7227-7234; doi:10.3390/molecules15107227

Efficient Microwave-Assisted Synthesis of 5-Deazaflavine Derivatives

1,* , 1, 1, 2,* , 3,* , 3 and 3
1 Grupo de Investigación en Compuestos Heterocíclicos, Programa de Química, Facultad de Ciencias Básicas, Universidad del Atlántico, A.A.1890 Barranquilla, Colombia 2 Grupo de Investigación de Compuestos Heterocíclicos, Departamento de Química, Universidad del Valle, A. A. 25360 Cali, Colombia 3 Departamento de Química Inorgánica y Orgánica, Universidad de Jaén, 23071 Jaén, Spain
* Authors to whom correspondence should be addressed.
Received: 16 September 2010 / Revised: 30 September 2010 / Accepted: 3 October 2010 / Published: 20 October 2010
(This article belongs to the Section Organic Synthesis)
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A series of pyrimido[4,5-b]quinolines  (5-deazaflavines), were synthesized by microwave assisted intramolecular cyclization. The N4-substituted-2,4-diamino-6-chloro-pyrimidine-5-carbaldehydes, were prepared by selective monoamination of 2-amino-4,6-dichloropyrimidine-5-carbaldehyde with aliphatic and aromatic amines.
Keywords: pyrimidoquinolines; cyclocondensation; microwave; deazaflavines pyrimidoquinolines; cyclocondensation; microwave; deazaflavines
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Trilleras, J.; López, L.G.; Pacheco, D.J.; Quiroga, J.; Nogueras, M.; Torre, J.M.; Cobo, J. Efficient Microwave-Assisted Synthesis of 5-Deazaflavine Derivatives. Molecules 2010, 15, 7227-7234.

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