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Molecules 2010, 15(10), 7227-7234; doi:10.3390/molecules15107227
Communication

Efficient Microwave-Assisted Synthesis of 5-Deazaflavine Derivatives

1,* , 1, 1, 2,* , 3,* , 3 and 3
Received: 16 September 2010 / Revised: 30 September 2010 / Accepted: 3 October 2010 / Published: 20 October 2010
(This article belongs to the Section Organic Synthesis)
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Abstract

A series of pyrimido[4,5-b]quinolines  (5-deazaflavines), were synthesized by microwave assisted intramolecular cyclization. The N4-substituted-2,4-diamino-6-chloro-pyrimidine-5-carbaldehydes, were prepared by selective monoamination of 2-amino-4,6-dichloropyrimidine-5-carbaldehyde with aliphatic and aromatic amines.
Keywords: pyrimidoquinolines; cyclocondensation; microwave; deazaflavines pyrimidoquinolines; cyclocondensation; microwave; deazaflavines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Trilleras, J.; López, L.G.; Pacheco, D.J.; Quiroga, J.; Nogueras, M.; Torre, J.M.; Cobo, J. Efficient Microwave-Assisted Synthesis of 5-Deazaflavine Derivatives. Molecules 2010, 15, 7227-7234.

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