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Molecules 2010, 15(10), 7227-7234; doi:10.3390/molecules15107227

Efficient Microwave-Assisted Synthesis of 5-Deazaflavine Derivatives

1,* , 1, 1, 2,* , 3,* , 3 and 3
Received: 16 September 2010 / Revised: 30 September 2010 / Accepted: 3 October 2010 / Published: 20 October 2010
(This article belongs to the Section Organic Synthesis)
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Abstract: A series of pyrimido[4,5-b]quinolines  (5-deazaflavines), were synthesized by microwave assisted intramolecular cyclization. The N4-substituted-2,4-diamino-6-chloro-pyrimidine-5-carbaldehydes, were prepared by selective monoamination of 2-amino-4,6-dichloropyrimidine-5-carbaldehyde with aliphatic and aromatic amines.
Keywords: pyrimidoquinolines; cyclocondensation; microwave; deazaflavines pyrimidoquinolines; cyclocondensation; microwave; deazaflavines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Trilleras, J.; López, L.G.; Pacheco, D.J.; Quiroga, J.; Nogueras, M.; Torre, J.M.; Cobo, J. Efficient Microwave-Assisted Synthesis of 5-Deazaflavine Derivatives. Molecules 2010, 15, 7227-7234.

AMA Style

Trilleras J, López LG, Pacheco DJ, Quiroga J, Nogueras M, Torre JM, Cobo J. Efficient Microwave-Assisted Synthesis of 5-Deazaflavine Derivatives. Molecules. 2010; 15(10):7227-7234.

Chicago/Turabian Style

Trilleras, Jorge; López, Luis Gabriel; Pacheco, Dency José; Quiroga, Jairo; Nogueras, Manuel; Torre, José M. de la; Cobo, Justo. 2010. "Efficient Microwave-Assisted Synthesis of 5-Deazaflavine Derivatives." Molecules 15, no. 10: 7227-7234.

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