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Molecules 2010, 15(10), 7227-7234; doi:10.3390/molecules15107227

Efficient Microwave-Assisted Synthesis of 5-Deazaflavine Derivatives

1
Grupo de Investigación en Compuestos Heterocíclicos, Programa de Química, Facultad de Ciencias Básicas, Universidad del Atlántico, A.A.1890 Barranquilla, Colombia
2
Grupo de Investigación de Compuestos Heterocíclicos, Departamento de Química, Universidad del Valle, A. A. 25360 Cali, Colombia
3
Departamento de Química Inorgánica y Orgánica, Universidad de Jaén, 23071 Jaén, Spain
*
Authors to whom correspondence should be addressed.
Received: 16 September 2010 / Revised: 30 September 2010 / Accepted: 3 October 2010 / Published: 20 October 2010
(This article belongs to the Section Organic Synthesis)
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Abstract

A series of pyrimido[4,5-b]quinolines  (5-deazaflavines), were synthesized by microwave assisted intramolecular cyclization. The N4-substituted-2,4-diamino-6-chloro-pyrimidine-5-carbaldehydes, were prepared by selective monoamination of 2-amino-4,6-dichloropyrimidine-5-carbaldehyde with aliphatic and aromatic amines.
Keywords: pyrimidoquinolines; cyclocondensation; microwave; deazaflavines pyrimidoquinolines; cyclocondensation; microwave; deazaflavines
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Trilleras, J.; López, L.G.; Pacheco, D.J.; Quiroga, J.; Nogueras, M.; Torre, J.M.; Cobo, J. Efficient Microwave-Assisted Synthesis of 5-Deazaflavine Derivatives. Molecules 2010, 15, 7227-7234.

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