Molecules 2010, 15(10), 7208-7217; doi:10.3390/molecules15107208
Article

The Beneficial Effect of Vanillic Acid on Ulcerative Colitis

1,†email, 2,†email, 1email and 2,* email
Received: 1 September 2010; in revised form: 8 October 2010 / Accepted: 18 October 2010 / Published: 19 October 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Vanillic acid, an oxidized form of vanillin, is a benzoic acid derivative used as a flavoring agent. The objective of this study was to determine whether vanillic acid has beneficial effects against dextran sulfate sodium (DSS)-induced ulcerative colitis. Our results showed that vanillic acid reduced the severity of the clinical signs of DSS-induced colitis, including weight loss and shortening of colon length, and the disease activity index. The results of this study showed that vanillic acid significantly suppressed the expression of cyclooxygenase-2 and the activation of transcription nuclear factor-kB p65 in DSS-treated colon tissues. In addition, we observed that the plasma levels of interleukin (IL)-6 were higher in the DSS-treated group than in the control group, but these increased levels were reduced by the administration of vanillic acid. Taken together, these findings suggest that vanillic acid has a beneficial effect on DSS-induced ulcerative colitis, thereby indicating its usefulness in the regulation of chronic intestinal inflammation.
Keywords: vanillic acid; dextran sulfate sodium; ulcerative colitis; cyclooxygenase-2; nuclear factor-κB p65; interleukin-6
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MDPI and ACS Style

Kim, S.-J.; Kim, M.-C.; Um, J.-Y.; Hong, S.-H. The Beneficial Effect of Vanillic Acid on Ulcerative Colitis. Molecules 2010, 15, 7208-7217.

AMA Style

Kim S-J, Kim M-C, Um J-Y, Hong S-H. The Beneficial Effect of Vanillic Acid on Ulcerative Colitis. Molecules. 2010; 15(10):7208-7217.

Chicago/Turabian Style

Kim, Su-Jin; Kim, Min-Cheol; Um, Jae-Young; Hong, Seung-Heon. 2010. "The Beneficial Effect of Vanillic Acid on Ulcerative Colitis." Molecules 15, no. 10: 7208-7217.

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