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Molecules 2010, 15(10), 7115-7124; doi:10.3390/molecules15107115
Article

Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle

1, 2, 3, 4 and 5,*
1 Department of Otolaryngology, Chi Mei Medical Center, Liouying, Tainan, 717, Taiwan 2 Department of Applied Life Science and Health, Chia-Nan University of Pharmacy and Science, 60 Erh-Jen Road, Sec. 1, Jen-Te Hsiang, Tainan, 717, Taiwan 3 Institute of Microbiology and Biochemistry, National Taiwan University, Taipei, 106, Taiwan 4 Molecular Genetics Laboratory, Department of Microbiology and Immunology, Chang-Gung University, Taoyuan, 333, Taiwan 5 Department of Health and Nutrition, Chia-Nan University of Pharmacy and Science, 60 Erh-Jen Road, Sec. 1, Jen-Te Hsiang, Tainan, 717, Taiwan
* Author to whom correspondence should be addressed.
Received: 7 September 2010 / Revised: 11 October 2010 / Accepted: 13 October 2010 / Published: 14 October 2010
(This article belongs to the Section Metabolites)
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Abstract

Reactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expression of EBV lytic proteins, including Rta, Zta, and EA-D and reduces viron production, suggesting that this compound may be useful for preventing the proliferation of the virus.
Keywords: resveratrol; antiviral activity; EBV resveratrol; antiviral activity; EBV
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Yiu, C.-Y.; Chen, S.-Y.; Chang, L.-K.; Chiu, Y.-F.; Lin, T.-P. Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle. Molecules 2010, 15, 7115-7124.

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