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Molecules 2010, 15(10), 7106-7114; doi:10.3390/molecules15107106
Article

A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds

1
,
2,* , 1
,
3
 and
1
1 Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 1 avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France 2 UPS2561, CNRS, 2, avenue Gustave Charlery, 97300 Cayenne, France 3 Muséum National d’Histoire Naturelle, FRE 3206 CNRS, CP52, 61 rue Buffon, 75231 Paris cedex 05, France
* Author to whom correspondence should be addressed.
Received: 21 August 2010 / Revised: 23 September 2010 / Accepted: 3 October 2010 / Published: 14 October 2010
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Abstract

Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7-geranyl-xanthone (1), together with four known compounds 2-5. These compounds were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) and for their cytotoxicity against the human diploid embryonic lung cell line MRC-5.
Keywords: Rheedia acuminata; Clusiaceae; xanthones; antiplasmodial activity; cytotoxicity Rheedia acuminata; Clusiaceae; xanthones; antiplasmodial activity; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Marti, G.; Eparvier, V.; Litaudon, M.; Grellier, P.; Guéritte, F. A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds. Molecules 2010, 15, 7106-7114.

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