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Molecules 2010, 15(10), 7106-7114; doi:10.3390/molecules15107106
Article

A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds

1
, 2,* , 1
, 3
 and 1
1 Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 1 avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France 2 UPS2561, CNRS, 2, avenue Gustave Charlery, 97300 Cayenne, France 3 Muséum National d’Histoire Naturelle, FRE 3206 CNRS, CP52, 61 rue Buffon, 75231 Paris cedex 05, France
* Author to whom correspondence should be addressed.
Received: 21 August 2010 / Revised: 23 September 2010 / Accepted: 3 October 2010 / Published: 14 October 2010
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Abstract

Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7-geranyl-xanthone (1), together with four known compounds 2-5. These compounds were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) and for their cytotoxicity against the human diploid embryonic lung cell line MRC-5.
Keywords: Rheedia acuminata; Clusiaceae; xanthones; antiplasmodial activity; cytotoxicity Rheedia acuminata; Clusiaceae; xanthones; antiplasmodial activity; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Marti, G.; Eparvier, V.; Litaudon, M.; Grellier, P.; Guéritte, F. A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds. Molecules 2010, 15, 7106-7114.

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