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Molecules 2010, 15(10), 6941-6947; doi:10.3390/molecules15106941

Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs

, ,  and *
National Institute for Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, China
* Author to whom correspondence should be addressed.
Received: 4 August 2010 / Revised: 6 September 2010 / Accepted: 25 September 2010 / Published: 8 October 2010
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A series of 1-acyl-3-(2'-aminophenyl) thiourea derivatives were designed and synthesized. The structures of all the newly synthesized compounds were identified by IR, elemental analysis, 1H-NMR and 13C-NMR. Their anti-intestinal nematode activities against Nippostrongylus brazilliensis were evaluated in rats by an oral route. Among these compounds, at concentrations of 10 mg/kg of rat, compound (1-(2'-furanyl)acyl-3- (2'-aminophenyl) thiourea) (5h) produced the highest activity with 89.4% deparasitization. The present work suggests that 1-acyl-3-(2'-aminophenyl) thiourea derivatives may become useful  lead compounds for anti-intestinal nematode treatment.
Keywords: acyl; thiourea; deparasitization; Nippostrongylus brazilliensis acyl; thiourea; deparasitization; Nippostrongylus brazilliensis
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Duan, L.-P.; Xue, J.; Xu, L.-L.; Zhang, H.-B. Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs. Molecules 2010, 15, 6941-6947.

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