Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs

doi:10.3390/molecules15106941

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Molecules 2010, 15(10), 6941-6947; doi:10.3390/molecules15106941

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Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs

Li-Ping Duan, Jia Xue, Li-Li Xu and Hao-Bing Zhang*

National Institute for Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, China

* Author to whom correspondence should be addressed.

Received: 4 August 2010; in revised form: 6 September 2010 / Accepted: 25 September 2010 / Published: 8 October 2010

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Abstract: A series of 1-acyl-3-(2'-aminophenyl) thiourea derivatives were designed and synthesized. The structures of all the newly synthesized compounds were identified by IR, elemental analysis, ¹H-NMR and ¹³C-NMR. Their anti-intestinal nematode activities against Nippostrongylus brazilliensis were evaluated in rats by an oral route. Among these compounds, at concentrations of 10 mg/kg of rat, compound (1-(2'-furanyl)acyl-3- (2'-aminophenyl) thiourea) (5h) produced the highest activity with 89.4% deparasitization. The present work suggests that 1-acyl-3-(2'-aminophenyl) thiourea derivatives may become useful lead compounds for anti-intestinal nematode treatment.

Keywords: acyl; thiourea; deparasitization; Nippostrongylus brazilliensis

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MDPI and ACS Style

Duan, L.-P.; Xue, J.; Xu, L.-L.; Zhang, H.-B. Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs. Molecules 2010, 15, 6941-6947.

AMA Style

Duan L-P, Xue J, Xu L-L, Zhang H-B. Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs. Molecules. 2010; 15(10):6941-6947.

Chicago/Turabian Style

Duan, Li-Ping; Xue, Jia; Xu, Li-Li; Zhang, Hao-Bing. 2010. "Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs." Molecules 15, no. 10: 6941-6947.

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