Next Article in Journal
Component Analysis and Free Radicals Scavenging Activity of Cicer arietinum L. Husk Pectin
Previous Article in Journal
Prodigiosin Production by Serratia marcescens UCP 1549 Using Renewable-Resources as a Low Cost Substrate
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2010, 15(10), 6941-6947; doi:10.3390/molecules15106941

Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs

National Institute for Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, China
Author to whom correspondence should be addressed.
Received: 4 August 2010 / Revised: 6 September 2010 / Accepted: 25 September 2010 / Published: 8 October 2010
Download PDF [148 KB, uploaded 18 June 2014]


A series of 1-acyl-3-(2'-aminophenyl) thiourea derivatives were designed and synthesized. The structures of all the newly synthesized compounds were identified by IR, elemental analysis, 1H-NMR and 13C-NMR. Their anti-intestinal nematode activities against Nippostrongylus brazilliensis were evaluated in rats by an oral route. Among these compounds, at concentrations of 10 mg/kg of rat, compound (1-(2'-furanyl)acyl-3- (2'-aminophenyl) thiourea) (5h) produced the highest activity with 89.4% deparasitization. The present work suggests that 1-acyl-3-(2'-aminophenyl) thiourea derivatives may become useful lead compounds for anti-intestinal nematode treatment.
Keywords: acyl; thiourea; deparasitization; Nippostrongylus brazilliensis acyl; thiourea; deparasitization; Nippostrongylus brazilliensis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Duan, L.-P.; Xue, J.; Xu, L.-L.; Zhang, H.-B. Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs. Molecules 2010, 15, 6941-6947.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top