Next Article in Journal
Conversion of Natural Aldehydes from Eucalyptus citriodora, Cymbopogon citratus, and Lippia multiflora into Oximes: GC-MS and FT-IR Analysis
Previous Article in Journal
Antiproliferative, Cytotoxic, Antioxidant Activity and Polyphenols Contents in Leaves of Four Staphylea L. Species
Article Menu

Article Versions

Export Article

Open AccessCommunication
Molecules 2009, 14(9), 3268-3274; doi:10.3390/molecules14093268

Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug

1
Department of Pharmaceutical Sciences, University of Ferrara, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy
2
Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy
3
Ambrosialab srl, Via Saragat 4a, I-44100 Ferrara, Italy
#
Current address: Specchiasol srl, Via Bruno Rizzi 37012 Bussolengo, Italy
Current address: National University of Ireland, Galway, Ireland
*
Author to whom correspondence should be addressed.
Received: 27 July 2009 / Revised: 25 August 2009 / Accepted: 27 August 2009 / Published: 31 August 2009
Download PDF [101 KB, uploaded 18 June 2014]   |  

Abstract

As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.
Keywords: L-carnitine; molecular conjugation; increased brain delivery; prodrug; nipecotic acid L-carnitine; molecular conjugation; increased brain delivery; prodrug; nipecotic acid
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Napolitano, C.; Scaglianti, M.; Scalambra, E.; Manfredini, S.; Ferraro, L.; Beggiato, S.; Vertuani, S. Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug. Molecules 2009, 14, 3268-3274.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top