Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug

doi:10.3390/molecules14093268

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Molecules 2009, 14(9), 3268-3274; doi:10.3390/molecules14093268

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Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug

Carmela Napolitano^1,#, Martina Scaglianti^1,†, Emanuela Scalambra¹, Stefano Manfredini^1,3,* , Luca Ferraro², Sarah Beggiato² and Silvia Vertuani^1,3

¹ Department of Pharmaceutical Sciences, University of Ferrara, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy ² Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy ³ Ambrosialab srl, Via Saragat 4a, I-44100 Ferrara, Italy ^# Current address: Specchiasol srl, Via Bruno Rizzi 37012 Bussolengo, Italy ^† Current address: National University of Ireland, Galway, Ireland

* Author to whom correspondence should be addressed.

Received: 27 July 2009; in revised form: 25 August 2009 / Accepted: 27 August 2009 / Published: 31 August 2009

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Abstract: As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.

Keywords: L-carnitine; molecular conjugation; increased brain delivery; prodrug; nipecotic acid

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MDPI and ACS Style

Napolitano, C.; Scaglianti, M.; Scalambra, E.; Manfredini, S.; Ferraro, L.; Beggiato, S.; Vertuani, S. Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug. Molecules 2009, 14, 3268-3274.

AMA Style

Napolitano C., Scaglianti M., Scalambra E., Manfredini S., Ferraro L., Beggiato S., Vertuani S. Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug. Molecules. 2009; 14(9):3268-3274.

Chicago/Turabian Style

Napolitano, Carmela; Scaglianti, Martina; Scalambra, Emanuela; Manfredini, Stefano; Ferraro, Luca; Beggiato, Sarah; Vertuani, Silvia. 2009. "Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug." Molecules 14, no. 9: 3268-3274.

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