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Molecules 2009, 14(9), 3268-3274; doi:10.3390/molecules14093268
Communication

Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug

1,#, 1,†, 1, 1,3,* , 2, 2 and 1,3
1 Department of Pharmaceutical Sciences, University of Ferrara, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy 2 Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy 3 Ambrosialab srl, Via Saragat 4a, I-44100 Ferrara, Italy # Current address: Specchiasol srl, Via Bruno Rizzi 37012 Bussolengo, Italy Current address: National University of Ireland, Galway, Ireland
* Author to whom correspondence should be addressed.
Received: 27 July 2009 / Revised: 25 August 2009 / Accepted: 27 August 2009 / Published: 31 August 2009
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Abstract

As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.
Keywords: L-carnitine; molecular conjugation; increased brain delivery; prodrug; nipecotic acid L-carnitine; molecular conjugation; increased brain delivery; prodrug; nipecotic acid
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Napolitano, C.; Scaglianti, M.; Scalambra, E.; Manfredini, S.; Ferraro, L.; Beggiato, S.; Vertuani, S. Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug. Molecules 2009, 14, 3268-3274.

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