Molecules 2009, 14(9), 3268-3274; doi:10.3390/molecules14093268
Communication

Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug

1,#, 1,†, 1, 1,3,* email, 2, 2 and 1,3
Received: 27 July 2009; in revised form: 25 August 2009 / Accepted: 27 August 2009 / Published: 31 August 2009
Download PDF [101 KB, uploaded 18 June 2014]
Abstract: As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.
Keywords: L-carnitine; molecular conjugation; increased brain delivery; prodrug; nipecotic acid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Napolitano, C.; Scaglianti, M.; Scalambra, E.; Manfredini, S.; Ferraro, L.; Beggiato, S.; Vertuani, S. Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug. Molecules 2009, 14, 3268-3274.

AMA Style

Napolitano C, Scaglianti M, Scalambra E, Manfredini S, Ferraro L, Beggiato S, Vertuani S. Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug. Molecules. 2009; 14(9):3268-3274.

Chicago/Turabian Style

Napolitano, Carmela; Scaglianti, Martina; Scalambra, Emanuela; Manfredini, Stefano; Ferraro, Luca; Beggiato, Sarah; Vertuani, Silvia. 2009. "Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug." Molecules 14, no. 9: 3268-3274.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert