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Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug
Department of Pharmaceutical Sciences, University of Ferrara, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy
Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy
Ambrosialab srl, Via Saragat 4a, I-44100 Ferrara, Italy
Current address: Specchiasol srl, Via Bruno Rizzi 37012 Bussolengo, Italy
Current address: National University of Ireland, Galway, Ireland
* Author to whom correspondence should be addressed.
Received: 27 July 2009 / Revised: 25 August 2009 / Accepted: 27 August 2009 / Published: 31 August 2009
Abstract As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.
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Napolitano, C.; Scaglianti, M.; Scalambra, E.; Manfredini, S.; Ferraro, L.; Beggiato, S.; Vertuani, S. Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug. Molecules 2009, 14, 3268-3274.
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Napolitano C, Scaglianti M, Scalambra E, Manfredini S, Ferraro L, Beggiato S, Vertuani S. Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug. Molecules. 2009; 14(9):3268-3274.
Napolitano, Carmela; Scaglianti, Martina; Scalambra, Emanuela; Manfredini, Stefano; Ferraro, Luca; Beggiato, Sarah; Vertuani, Silvia. 2009. "Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug." Molecules 14, no. 9: 3268-3274.
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