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Molecules 2009, 14(9), 3268-3274; doi:10.3390/molecules14093268
Communication

Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug

1,#, 1,†, 1, 1,3,* , 2, 2 and 1,3
1 Department of Pharmaceutical Sciences, University of Ferrara, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy 2 Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy 3 Ambrosialab srl, Via Saragat 4a, I-44100 Ferrara, Italy # Current address: Specchiasol srl, Via Bruno Rizzi 37012 Bussolengo, Italy Current address: National University of Ireland, Galway, Ireland
* Author to whom correspondence should be addressed.
Received: 27 July 2009 / Revised: 25 August 2009 / Accepted: 27 August 2009 / Published: 31 August 2009
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Abstract

As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.
Keywords: L-carnitine; molecular conjugation; increased brain delivery; prodrug; nipecotic acid L-carnitine; molecular conjugation; increased brain delivery; prodrug; nipecotic acid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Napolitano, C.; Scaglianti, M.; Scalambra, E.; Manfredini, S.; Ferraro, L.; Beggiato, S.; Vertuani, S. Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug. Molecules 2009, 14, 3268-3274.

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