Molecular Docking Studies and Anti−Snake Venom Metalloproteinase Activity of Thai Mango Seed Kernel Extract
Abstract
:1. Introduction
2. Results and Discussion
2.1. In vitro test for the inhibition of caseinolytic activity
2.2. In vitro test for the inhibition of fibrinogenolytic activity
2.3. Molecular modeling
2.3.1. Docking into the rhodostoxin structure
2.3.2. Docking into kaouthiagin structure
3. Experimental
3.1. Chemicals and venoms
3.2. Plant material and extraction
3.3. Standardization
3.4. In vitro test for the inhibition of caseinolytic activity
3.5. In vitro test for the inhibition of fibrinogenolytic activity
3.6. Molecular modeling
3.7. Statistical analysis
4. Conclusions
Acknowledgements
References
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Sample Availability: Samples of the compounds are available from the authors. |
MSKE constituents | GoldScore | |
---|---|---|
Rhodostoxin | Kaouthiagin | |
(CR venom) | (NK venom) | |
GA | 47.13 | 47.70 |
MG | 39.04 | 48.70 |
PGG | 83.08 | 76.45 |
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Pithayanukul, P.; Leanpolchareanchai, J.; Saparpakorn, P. Molecular Docking Studies and Anti−Snake Venom Metalloproteinase Activity of Thai Mango Seed Kernel Extract. Molecules 2009, 14, 3198-3213. https://doi.org/10.3390/molecules14093198
Pithayanukul P, Leanpolchareanchai J, Saparpakorn P. Molecular Docking Studies and Anti−Snake Venom Metalloproteinase Activity of Thai Mango Seed Kernel Extract. Molecules. 2009; 14(9):3198-3213. https://doi.org/10.3390/molecules14093198
Chicago/Turabian StylePithayanukul, Pimolpan, Jiraporn Leanpolchareanchai, and Patchreenart Saparpakorn. 2009. "Molecular Docking Studies and Anti−Snake Venom Metalloproteinase Activity of Thai Mango Seed Kernel Extract" Molecules 14, no. 9: 3198-3213. https://doi.org/10.3390/molecules14093198