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Molecules 2009, 14(9), 3153-3160; doi:10.3390/molecules14093153

Synthesis of Novel 3,5-Dichloro-2-arylpyridines by Palladium Acetate-Catalyzed Ligand-Free Suzuki Reactions in Aqueous Media

1
College of Pharmaceutial and Chemical Engineering, Taizhou University, Linhai 317000, China
2
Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China
3
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China
*
Author to whom correspondence should be addressed.
Received: 19 July 2009 / Revised: 18 August 2009 / Accepted: 25 August 2009 / Published: 26 August 2009
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Abstract

A highly efficient palladium acetate-catalyzed ligand-free Suzuki reaction of 2,3,5-trichloropyridine with arylboronic acids in aqueous phase was developed. High yields of 3,5-dichloro-2-arylpyridines, a simple Pd source, absence of ligands, and environmentally benign as well as mild reaction conditions are important features of this method.
Keywords: Suzuki reaction; ligand-free; aqueous phase; 2; 3; 5-trichloropyridine; 3; 5-dichloro-2-arylpyridines Suzuki reaction; ligand-free; aqueous phase; 2; 3; 5-trichloropyridine; 3; 5-dichloro-2-arylpyridines
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Hu, H.; Ge, C.; Zhang, A.; Ding, L. Synthesis of Novel 3,5-Dichloro-2-arylpyridines by Palladium Acetate-Catalyzed Ligand-Free Suzuki Reactions in Aqueous Media. Molecules 2009, 14, 3153-3160.

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