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Molecules 2009, 14(9), 3153-3160; doi:10.3390/molecules14093153
Article

Synthesis of Novel 3,5-Dichloro-2-arylpyridines by Palladium Acetate-Catalyzed Ligand-Free Suzuki Reactions in Aqueous Media

1,* , 1, 2 and 3
1 College of Pharmaceutial and Chemical Engineering, Taizhou University, Linhai 317000, China 2 Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China 3 Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China
* Author to whom correspondence should be addressed.
Received: 19 July 2009 / Revised: 18 August 2009 / Accepted: 25 August 2009 / Published: 26 August 2009
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Abstract

A highly efficient palladium acetate-catalyzed ligand-free Suzuki reaction of 2,3,5-trichloropyridine with arylboronic acids in aqueous phase was developed. High yields of 3,5-dichloro-2-arylpyridines, a simple Pd source, absence of ligands, and environmentally benign as well as mild reaction conditions are important features of this method.
Keywords: Suzuki reaction; ligand-free; aqueous phase; 2; 3; 5-trichloropyridine; 3; 5-dichloro-2-arylpyridines Suzuki reaction; ligand-free; aqueous phase; 2; 3; 5-trichloropyridine; 3; 5-dichloro-2-arylpyridines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hu, H.; Ge, C.; Zhang, A.; Ding, L. Synthesis of Novel 3,5-Dichloro-2-arylpyridines by Palladium Acetate-Catalyzed Ligand-Free Suzuki Reactions in Aqueous Media. Molecules 2009, 14, 3153-3160.

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