Molecules 2009, 14(9), 3142-3152; doi:10.3390/molecules14093142
Article

Synthesis and Antitumor Activity of Amino Acid Ester Derivatives Containing 5-Fluorouracil

1,2,* email, 1, 1, 1, 1, 2 and 2,* email
Received: 15 July 2009; in revised form: 18 August 2009 / Accepted: 20 August 2009 / Published: 25 August 2009
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A series of amino acid ester derivatives containing 5-fluorouracil were synthesized using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC•HCl) and N-hydroxybenzotriazole (HOBt) as a coupling agent. The structures of the products were assigned by NMR, MS, IR etc. The in vitro antitumor activity tests against leukaemia HL-60 and liver cancer BEL-7402 indicated that (R)-ethyl 2-(2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)-3-(4-hydroxyphenyl) propanoate showed more inhibitory effect against BEL-7402 than 5-FU.
Keywords: 5-fluorouracil; amino acid ester; antitumor activity
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MDPI and ACS Style

Xiong, J.; Zhu, H.-F.; Zhao, Y.-J.; Lan, Y.-J.; Jiang, J.-W.; Yang, J.-J.; Zhang, S.-F. Synthesis and Antitumor Activity of Amino Acid Ester Derivatives Containing 5-Fluorouracil. Molecules 2009, 14, 3142-3152.

AMA Style

Xiong J, Zhu H-F, Zhao Y-J, Lan Y-J, Jiang J-W, Yang J-J, Zhang S-F. Synthesis and Antitumor Activity of Amino Acid Ester Derivatives Containing 5-Fluorouracil. Molecules. 2009; 14(9):3142-3152.

Chicago/Turabian Style

Xiong, Jing; Zhu, Hai-Feng; Zhao, Ya-Juan; Lan, Yun-Jun; Jiang, Ji-Wang; Yang, Jing-Jing; Zhang, Shu-Feng. 2009. "Synthesis and Antitumor Activity of Amino Acid Ester Derivatives Containing 5-Fluorouracil." Molecules 14, no. 9: 3142-3152.

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