Next Article in Journal
Solid State Polyselenides and Polytellurides: A Large Variety of Se–Se and Te–Te Interactions
Next Article in Special Issue
The Vitamin Nicotinamide: Translating Nutrition into Clinical Care
Previous Article in Journal
Evolution of the Yields and Composition of Essential Oil from Portuguese Myrtle (Myrtus comunis L.) through the Vegetative Cycle
Molecules 2009, 14(8), 3106-3114; doi:10.3390/molecules14083106
Article

Production of β-Maltooligosaccharides of α- and δ-Tocopherols by Klebsiella pneumoniae and Cyclodextrin Glucanotransferase as Anti-Allergic Agents

1,* , 2 and 3,*
1 Department of Chemistry, Faculty of Medicine, Oita University, 1-1 Hasama-machi, Oita 879-5593, Japan 2 Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan 3 Department of Life Science, Okayama University of Science, 1-1 Ridai-cho, Okayama 700-0005, Japan
* Authors to whom correspondence should be addressed.
Received: 14 July 2009 / Revised: 19 August 2009 / Accepted: 20 August 2009 / Published: 20 August 2009
(This article belongs to the Special Issue Vitamins)
View Full-Text   |   Download PDF [139 KB, uploaded 18 June 2014]   |   Browse Figure

Abstract

The glycosylation of α- and δ-tocopherols using Klebsiella pneumoniae and cyclodextrin glucanotransferase (CGTase) was investigated. K. pneumoniae converted α- and δ-tocopherols into the corresponding β-glucosides in 10 and 8% yield, respectively. CGTase glycosylated α-tocopheryl β-glucoside to α-tocopheryl β-maltoside (51%) and α-tocopheryl β-maltotrioside (35%). On the other hand, δ-tocopheryl β-glucoside was converted into the corresponding β-maltoside (45%) and β-maltotrioside (29%) by CGTase. The β-glucoside of α-tocopherol, and β-glucoside and β-maltoside of δ-tocopherol showed inhibitory effects on IgE antibody production and on histamine release from rat peritoneal mast cells.
Keywords: tocopherol; Klebsiella pneumoniae; cyclodextrin glucanotransferase; β-maltooligosaccharide; anti-allergic activity tocopherol; Klebsiella pneumoniae; cyclodextrin glucanotransferase; β-maltooligosaccharide; anti-allergic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Shimoda, K.; Akagi, M.; Hamada, H. Production of β-Maltooligosaccharides of α- and δ-Tocopherols by Klebsiella pneumoniae and Cyclodextrin Glucanotransferase as Anti-Allergic Agents. Molecules 2009, 14, 3106-3114.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert