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Molecules 2009, 14(8), 3106-3114; doi:10.3390/molecules14083106

Production of β-Maltooligosaccharides of α- and δ-Tocopherols by Klebsiella pneumoniae and Cyclodextrin Glucanotransferase as Anti-Allergic Agents

1
Department of Chemistry, Faculty of Medicine, Oita University, 1-1 Hasama-machi, Oita 879-5593, Japan
2
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan
3
Department of Life Science, Okayama University of Science, 1-1 Ridai-cho, Okayama 700-0005, Japan
*
Authors to whom correspondence should be addressed.
Received: 14 July 2009 / Revised: 19 August 2009 / Accepted: 20 August 2009 / Published: 20 August 2009
(This article belongs to the Special Issue Vitamins)
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Abstract

The glycosylation of α- and δ-tocopherols using Klebsiella pneumoniae and cyclodextrin glucanotransferase (CGTase) was investigated. K. pneumoniae converted α- and δ-tocopherols into the corresponding β-glucosides in 10 and 8% yield, respectively. CGTase glycosylated α-tocopheryl β-glucoside to α-tocopheryl β-maltoside (51%) and α-tocopheryl β-maltotrioside (35%). On the other hand, δ-tocopheryl β-glucoside was converted into the corresponding β-maltoside (45%) and β-maltotrioside (29%) by CGTase. The β-glucoside of α-tocopherol, and β-glucoside and β-maltoside of δ-tocopherol showed inhibitory effects on IgE antibody production and on histamine release from rat peritoneal mast cells.
Keywords: tocopherol; Klebsiella pneumoniae; cyclodextrin glucanotransferase; β-maltooligosaccharide; anti-allergic activity tocopherol; Klebsiella pneumoniae; cyclodextrin glucanotransferase; β-maltooligosaccharide; anti-allergic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Shimoda, K.; Akagi, M.; Hamada, H. Production of β-Maltooligosaccharides of α- and δ-Tocopherols by Klebsiella pneumoniae and Cyclodextrin Glucanotransferase as Anti-Allergic Agents. Molecules 2009, 14, 3106-3114.

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