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Molecules 2009, 14(8), 3037-3072; doi:10.3390/molecules14083037

Plant-Derived Antimalarial Agents: New Leads and Efficient Phytomedicines. Part II. Non-Alkaloidal Natural Products

Departamento de Estudos Básicos e Instrumentais, Universidade Estadual do Sudoeste da Bahia – UESB, BR 415, Km 03, s/nº, 45.700-000 Itapetinga, BA, Brazil
Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901 Belo Horizonte, MG, Brazil
Author to whom correspondence should be addressed.
Received: 9 July 2009 / Revised: 7 August 2009 / Accepted: 13 August 2009 / Published: 13 August 2009
(This article belongs to the Special Issue Neglected Diseases: Medicinal Chemistry and Natural Product Chemistry)


Malaria is still the most destructive and dangerous parasitic infection in many tropical and subtropical countries. The burden of this disease is getting worse, mainly due to the increasing resistance of Plasmodium falciparum against the widely available antimalarial drugs. There is an urgent need for new, more affordable and accessible antimalarial agents possessing original modes of action. Natural products have played a dominant role in the discovery of leads for the development of drugs to treat human diseases, and this fact anticipates that new antimalarial leads may certainly emerge from tropical plant sources. This present review covers most of the recently-published non-alkaloidal natural compounds from plants with antiplasmodial and antimalarial properties, belonging to the classes of terpenes, limonoids, flavonoids, chromones, xanthones, anthraquinones, miscellaneous and related compounds, besides the majority of papers describing antiplasmodial crude extracts published in the last five years not reviewed before. In addition, some perspectives and remarks on the development of new drugs and phytomedicines for malaria are succinctly discussed.
Keywords: malaria; non-alkaloidal natural products; Plasmodium; antiplasmodial activity malaria; non-alkaloidal natural products; Plasmodium; antiplasmodial activity

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Batista, R.; De Jesus Silva Júnior, A.; De Oliveira, A.B. Plant-Derived Antimalarial Agents: New Leads and Efficient Phytomedicines. Part II. Non-Alkaloidal Natural Products. Molecules 2009, 14, 3037-3072.

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