Molecules 2009, 14(8), 2699-2716; doi:10.3390/molecules14082699
Article

Influence of Different Polymer Types on the Overall Release Mechanism in Hydrophilic Matrix Tablets

Received: 25 June 2009; in revised form: 10 July 2009 / Accepted: 15 July 2009 / Published: 24 July 2009
(This article belongs to the Special Issue Macromolecules Applied to Pharmaceutics)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The effect of three different types of polymer chain structures on the polymer release from hydrophilic matrix tablets was investigated by comparing a synthetic semi-crystalline linear polymer (PEO), a branched amorphous polysaccharide (dextran) and an amorphous substituted cellulose derivative (HPMC). The polymer release rates for tablets containing mixtures of high and low molecular weight grades in different ratios were determined by using a modified USP II method and a SEC-RI chromatography system. The results showed that independent of polymer type: (i) plots of the release versus time had similar shapes, (ii) the release of long and short polymer chains was equal and no fractionation occurred during the release and (iii) the release rate could be related to the average intrinsic viscosity of the polymer mixtures. This confirms the hypothesis that the release rate can be related to a constant viscosity on the surface of the hydrophilic matrix tablet and that it is valid for all the investigated polymers.
Keywords: hydrophilic matrix tablets; release mechanism; intrinsic viscosity; PEO; HPMC; dextran
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MDPI and ACS Style

Körner, A.; Piculell, L.; Iselau, F.; Wittgren, B.; Larsson, A. Influence of Different Polymer Types on the Overall Release Mechanism in Hydrophilic Matrix Tablets. Molecules 2009, 14, 2699-2716.

AMA Style

Körner A, Piculell L, Iselau F, Wittgren B, Larsson A. Influence of Different Polymer Types on the Overall Release Mechanism in Hydrophilic Matrix Tablets. Molecules. 2009; 14(8):2699-2716.

Chicago/Turabian Style

Körner, Anna; Piculell, Lennart; Iselau, Frida; Wittgren, Bengt; Larsson, Anette. 2009. "Influence of Different Polymer Types on the Overall Release Mechanism in Hydrophilic Matrix Tablets." Molecules 14, no. 8: 2699-2716.

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