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Molecules 2009, 14(8), 2699-2716; doi:10.3390/molecules14082699

Influence of Different Polymer Types on the Overall Release Mechanism in Hydrophilic Matrix Tablets

1
SCA Hygiene Products, SE-405 03 Göteborg, Sweden
2
Department of Physical Chemistry 1, Lund University, Box 124, SE-221 00, Lund, Sweden
3
AstraZeneca R&D, SE-431 83, Mölndal, Sweden
4
Department of Chemistry and Bioengineering, Chalmers University of Technology, SE-412 96, Gothenburg, Sweden
*
Author to whom correspondence should be addressed.
Received: 25 June 2009 / Revised: 10 July 2009 / Accepted: 15 July 2009 / Published: 24 July 2009
(This article belongs to the Special Issue Macromolecules Applied to Pharmaceutics)
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Abstract

The effect of three different types of polymer chain structures on the polymer release from hydrophilic matrix tablets was investigated by comparing a synthetic semi-crystalline linear polymer (PEO), a branched amorphous polysaccharide (dextran) and an amorphous substituted cellulose derivative (HPMC). The polymer release rates for tablets containing mixtures of high and low molecular weight grades in different ratios were determined by using a modified USP II method and a SEC-RI chromatography system. The results showed that independent of polymer type: (i) plots of the release versus time had similar shapes, (ii) the release of long and short polymer chains was equal and no fractionation occurred during the release and (iii) the release rate could be related to the average intrinsic viscosity of the polymer mixtures. This confirms the hypothesis that the release rate can be related to a constant viscosity on the surface of the hydrophilic matrix tablet and that it is valid for all the investigated polymers.
Keywords: hydrophilic matrix tablets; release mechanism; intrinsic viscosity; PEO; HPMC; dextran hydrophilic matrix tablets; release mechanism; intrinsic viscosity; PEO; HPMC; dextran
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Körner, A.; Piculell, L.; Iselau, F.; Wittgren, B.; Larsson, A. Influence of Different Polymer Types on the Overall Release Mechanism in Hydrophilic Matrix Tablets. Molecules 2009, 14, 2699-2716.

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