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Influence of Different Polymer Types on the Overall Release Mechanism in Hydrophilic Matrix Tablets
SCA Hygiene Products, SE-405 03 Göteborg, Sweden
Department of Physical Chemistry 1, Lund University, Box 124, SE-221 00, Lund, Sweden
AstraZeneca R&D, SE-431 83, Mölndal, Sweden
Department of Chemistry and Bioengineering, Chalmers University of Technology, SE-412 96, Gothenburg, Sweden
* Author to whom correspondence should be addressed.
Received: 25 June 2009; in revised form: 10 July 2009 / Accepted: 15 July 2009 / Published: 24 July 2009
Abstract: The effect of three different types of polymer chain structures on the polymer release from hydrophilic matrix tablets was investigated by comparing a synthetic semi-crystalline linear polymer (PEO), a branched amorphous polysaccharide (dextran) and an amorphous substituted cellulose derivative (HPMC). The polymer release rates for tablets containing mixtures of high and low molecular weight grades in different ratios were determined by using a modified USP II method and a SEC-RI chromatography system. The results showed that independent of polymer type: (i) plots of the release versus time had similar shapes, (ii) the release of long and short polymer chains was equal and no fractionation occurred during the release and (iii) the release rate could be related to the average intrinsic viscosity of the polymer mixtures. This confirms the hypothesis that the release rate can be related to a constant viscosity on the surface of the hydrophilic matrix tablet and that it is valid for all the investigated polymers.
Keywords: hydrophilic matrix tablets; release mechanism; intrinsic viscosity; PEO; HPMC; dextran
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MDPI and ACS Style
Körner, A.; Piculell, L.; Iselau, F.; Wittgren, B.; Larsson, A. Influence of Different Polymer Types on the Overall Release Mechanism in Hydrophilic Matrix Tablets. Molecules 2009, 14, 2699-2716.
Körner A, Piculell L, Iselau F, Wittgren B, Larsson A. Influence of Different Polymer Types on the Overall Release Mechanism in Hydrophilic Matrix Tablets. Molecules. 2009; 14(8):2699-2716.
Körner, Anna; Piculell, Lennart; Iselau, Frida; Wittgren, Bengt; Larsson, Anette. 2009. "Influence of Different Polymer Types on the Overall Release Mechanism in Hydrophilic Matrix Tablets." Molecules 14, no. 8: 2699-2716.