Next Article in Journal
Experimental and Computational Studies on Non-Covalent Imprinted Microspheres as Recognition System for Nicotinamide Molecules
Previous Article in Journal
Polymeric Plant-derived Excipients in Drug Delivery
Molecules 2009, 14(7), 2621-2631; doi:10.3390/molecules14072621
Article

Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety

1
, 1
, 2,* , 3
, 4
 and 5
Received: 11 May 2009; in revised form: 24 June 2009 / Accepted: 8 July 2009 / Published: 16 July 2009
Download PDF [138 KB, uploaded 18 June 2014]
Abstract: New 1,3,4-thiadiazole, 6, 7 and 1,2,4-triazole derivatives, 8, 9 containing a phenylalanine moiety have been synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides, 4, 5, in acid and alkaline media, respectively; the thiosemicarbazides were obtained by reaction of hydrazide 3 with appropriate aromatic isothiocyanates. The toxicity of the synthesized compounds was evaluated and the anti-inflammatory study of the triazole compound 9 established an appreciable anti-inflammatory activity that is comparable with that of other nonsteroidal anti-inflammatory agents.
Keywords: phenylalanine; thiosemicarbazide; 1; 3; 4-thiadiazole; 1; 2; 4-triazole; anti-inflammatory activity phenylalanine; thiosemicarbazide; 1; 3; 4-thiadiazole; 1; 2; 4-triazole; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Moise, M.; Sunel, V.; Profire, L.; Popa, M.; Desbrieres, J.; Peptu, C. Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety. Molecules 2009, 14, 2621-2631.

AMA Style

Moise M, Sunel V, Profire L, Popa M, Desbrieres J, Peptu C. Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety. Molecules. 2009; 14(7):2621-2631.

Chicago/Turabian Style

Moise, Mihaela; Sunel, Valeriu; Profire, Lenuta; Popa, Marcel; Desbrieres, Jacques; Peptu, Cristian. 2009. "Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety." Molecules 14, no. 7: 2621-2631.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert