Next Article in Journal
Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety
Next Article in Special Issue
Physical Carboxymethylscleroglucan/Calcium Ion Hydrogels as Modified Drug Delivery Systems in Topical Formulations
Previous Article in Journal
Calixpyrrole Derivatives: “Multi Hydrogen Bond” Catalysts for γ-Butenolide Synthesis
Previous Article in Special Issue
Novel Biodegradable Polyesters. Synthesis and Application as Drug Carriers for the Preparation of Raloxifene HCl Loaded Nanoparticles
Molecules 2009, 14(7), 2602-2620; doi:10.3390/molecules14072602

Polymeric Plant-derived Excipients in Drug Delivery

Department of Pharmaceutical Sciences, Tshwane University of Technology, Private Bag X680, Pretoria, 0001, South Africa
* Author to whom correspondence should be addressed.
Received: 22 June 2009 / Revised: 1 July 2009 / Accepted: 6 July 2009 / Published: 16 July 2009
(This article belongs to the Special Issue Macromolecules Applied to Pharmaceutics)
View Full-Text   |   Download PDF [324 KB, uploaded 18 June 2014]   |   Browse Figures


Drug dosage forms contain many components in addition to the active pharmaceutical ingredient(s) to assist in the manufacturing process as well as to optimise drug delivery. Due to advances in drug delivery technology, excipients are currently included in novel dosage forms to fulfil specific functions and in some cases they directly or indirectly influence the extent and/or rate of drug release and absorption. Since plant polysaccharides comply with many requirements expected of pharmaceutical excipients such as non-toxicity, stability, availability and renewability they are extensively investigated for use in the development of solid oral dosage forms. Furthermore, polysaccharides with varying physicochemical properties can be extracted from plants at relatively low cost and can be chemically modified to suit specific needs. As an example, many polysaccharide-rich plant materials are successfully used as matrix formers in modified release dosage forms. Some natural polysaccharides have even shown environmental-responsive gelation characteristics with the potential to control drug release according to specific therapeutic needs. This review discusses some of the most important plant-derived polymeric compounds that are used or investigated as excipients in drug delivery systems.
Keywords: polysaccharide; polymer; excipient; drug delivery; controlled release; renewable resource polysaccharide; polymer; excipient; drug delivery; controlled release; renewable resource
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Beneke, C.E.; Viljoen, A.M.; Hamman, J.H. Polymeric Plant-derived Excipients in Drug Delivery. Molecules 2009, 14, 2602-2620.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert