Next Article in Journal
Chemical Composition of the Essential Oils from the Roots of Erigeron acris L. and Erigeron annuus (L.) Pers.
Previous Article in Journal
Synthesis and Antibacterial Activities of New Metronidazole and Imidazole Derivatives
Molecules 2009, 14(7), 2447-2457; doi:10.3390/molecules14072447

Synthesis of 3-N-Sugar-substituted-2, 4(1H,3H)-quinazolinedionesas Anti-Angiogenesis Agents

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
* Author to whom correspondence should be addressed.
Received: 8 May 2009 / Revised: 27 May 2009 / Accepted: 2 June 2009 / Published: 8 July 2009
Download PDF [267 KB, uploaded 18 June 2014]


A series of novel 3-N-sugar-substituted quinazolinediones were synthesizedthrough the cyclization of the intermediate 2-aminobenzamides using triphosgene as the condensing reagent. Their anti-angiogenesis activities were investigated. The compound 3-(2'-aminoglucosyl)-2,4-(1H,3H)-quinazolinedione, (5d) showed good anti-angiogenesis activity.
Keywords: quinazolinediones; anti-angiogenesis; triphosgene quinazolinediones; anti-angiogenesis; triphosgene
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Huang, C.; Meng, X.; Cui, J.; Li, Z. Synthesis of 3-N-Sugar-substituted-2, 4(1H,3H)-quinazolinedionesas Anti-Angiogenesis Agents. Molecules 2009, 14, 2447-2457.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert