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Molecules 2009, 14(7), 2447-2457; doi:10.3390/molecules14072447

Synthesis of 3-N-Sugar-substituted-2, 4(1H,3H)-quinazolinedionesas Anti-Angiogenesis Agents

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
* Author to whom correspondence should be addressed.
Received: 8 May 2009 / Revised: 27 May 2009 / Accepted: 2 June 2009 / Published: 8 July 2009
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A series of novel 3-N-sugar-substituted quinazolinediones were synthesizedthrough the cyclization of the intermediate 2-aminobenzamides using triphosgene as the condensing reagent. Their anti-angiogenesis activities were investigated. The compound 3-(2'-aminoglucosyl)-2,4-(1H,3H)-quinazolinedione, (5d) showed good anti-angiogenesis activity.
Keywords: quinazolinediones; anti-angiogenesis; triphosgene quinazolinediones; anti-angiogenesis; triphosgene
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Huang, C.; Meng, X.; Cui, J.; Li, Z. Synthesis of 3-N-Sugar-substituted-2, 4(1H,3H)-quinazolinedionesas Anti-Angiogenesis Agents. Molecules 2009, 14, 2447-2457.

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