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Molecules 2009, 14(7), 2447-2457; doi:10.3390/molecules14072447
Article

Synthesis of 3-N-Sugar-substituted-2, 4(1H,3H)-quinazolinedionesas Anti-Angiogenesis Agents

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Received: 8 May 2009; in revised form: 27 May 2009 / Accepted: 2 June 2009 / Published: 8 July 2009
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Abstract: A series of novel 3-N-sugar-substituted quinazolinediones were synthesizedthrough the cyclization of the intermediate 2-aminobenzamides using triphosgene as the condensing reagent. Their anti-angiogenesis activities were investigated. The compound 3-(2'-aminoglucosyl)-2,4-(1H,3H)-quinazolinedione, (5d) showed good anti-angiogenesis activity.
Keywords: quinazolinediones; anti-angiogenesis; triphosgene quinazolinediones; anti-angiogenesis; triphosgene
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Huang, C.; Meng, X.; Cui, J.; Li, Z. Synthesis of 3-N-Sugar-substituted-2, 4(1H,3H)-quinazolinedionesas Anti-Angiogenesis Agents. Molecules 2009, 14, 2447-2457.

AMA Style

Huang C, Meng X, Cui J, Li Z. Synthesis of 3-N-Sugar-substituted-2, 4(1H,3H)-quinazolinedionesas Anti-Angiogenesis Agents. Molecules. 2009; 14(7):2447-2457.

Chicago/Turabian Style

Huang, Conghai; Meng, Xiangbao; Cui, Jingrong; Li, Zhongjun. 2009. "Synthesis of 3-N-Sugar-substituted-2, 4(1H,3H)-quinazolinedionesas Anti-Angiogenesis Agents." Molecules 14, no. 7: 2447-2457.



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