Synthesis of 3-N-Sugar-substituted-2, 4(1H,3H)-quinazolinedionesas Anti-Angiogenesis Agents

doi:10.3390/molecules14072447

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Molecules 2009, 14(7), 2447-2457; doi:10.3390/molecules14072447

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Synthesis of 3-N-Sugar-substituted-2, 4(1H,3H)-quinazolinedionesas Anti-Angiogenesis Agents

Conghai Huang, Xiangbao Meng, Jingrong Cui and Zhongjun Li*

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

* Author to whom correspondence should be addressed.

Received: 8 May 2009; in revised form: 27 May 2009 / Accepted: 2 June 2009 / Published: 8 July 2009

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Abstract: A series of novel 3-N-sugar-substituted quinazolinediones were synthesizedthrough the cyclization of the intermediate 2-aminobenzamides using triphosgene as the condensing reagent. Their anti-angiogenesis activities were investigated. The compound 3-(2'-aminoglucosyl)-2,4-(1H,3H)-quinazolinedione, (5d) showed good anti-angiogenesis activity.

Keywords: quinazolinediones; anti-angiogenesis; triphosgene

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MDPI and ACS Style

Huang, C.; Meng, X.; Cui, J.; Li, Z. Synthesis of 3-N-Sugar-substituted-2, 4(1H,3H)-quinazolinedionesas Anti-Angiogenesis Agents. Molecules 2009, 14, 2447-2457.

AMA Style

Huang C, Meng X, Cui J, Li Z. Synthesis of 3-N-Sugar-substituted-2, 4(1H,3H)-quinazolinedionesas Anti-Angiogenesis Agents. Molecules. 2009; 14(7):2447-2457.

Chicago/Turabian Style

Huang, Conghai; Meng, Xiangbao; Cui, Jingrong; Li, Zhongjun. 2009. "Synthesis of 3-N-Sugar-substituted-2, 4(1H,3H)-quinazolinedionesas Anti-Angiogenesis Agents." Molecules 14, no. 7: 2447-2457.

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