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Molecules 2009, 14(7), 2431-2446; doi:10.3390/molecules14072431

Synthesis and Antibacterial Activities of New Metronidazole and Imidazole Derivatives

Department of Chemistry, College of Sciences, The University of Mustansiriayah, Iraq
Received: 17 May 2009 / Revised: 12 June 2009 / Accepted: 6 July 2009 / Published: 8 July 2009
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Abstract

New imidazole ring derivatives comprising 1,3-oxazoline, Schiff's bases, thiadiazole, oxadiazole and 1,2,4-triazole moieties are reported. 3-Aminobiimidazol-4-one compounds 7a-c were synthesized by the reaction of compounds 6a-c with hydrazine hydrate. Biimidazole esters 9a-c were converted into biimidazole hydrazide esters 10a-c. Compounds 7a-c and 10a-c were converted into a variety of derivatives.
Keywords: metronidazole; biimidazole; imidazole; 1; 3; 4-oxadiazole; 1; 2; 4-triazole; 1; 3; 4-thiadiazole metronidazole; biimidazole; imidazole; 1; 3; 4-oxadiazole; 1; 2; 4-triazole; 1; 3; 4-thiadiazole
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Atia, A.J.K. Synthesis and Antibacterial Activities of New Metronidazole and Imidazole Derivatives. Molecules 2009, 14, 2431-2446.

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