Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Molecules 2009, 14(7), 2373-2393; doi:10.3390/molecules14072373
Review

Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine

1
, 2
, 3
, 3
 and 3,*
Received: 27 May 2009; in revised form: 23 June 2009 / Accepted: 2 July 2009 / Published: 3 July 2009
(This article belongs to the Special Issue Triterpenes and Triterpenoids)
Download PDF [342 KB, uploaded 18 June 2014]
Abstract: Withania somnifera, commonly known as Ashwagandha, is an important medicinal plant that has been used in Ayurvedic and indigenous medicine for over 3,000 years. In view of its varied therapeutic potential, it has also been the subject of considerable modern scientific attention. The major chemical constituents of the Withania genus, the withanolides, are a group of naturally occurring C28-steroidal lactone triterpenoids built on an intact or rearranged ergostane framework, in which C-22 and C-26 are appropriately oxidized to form a six-membered lactone ring. In recent years, numerous pharmacological investigations have been carried out into the components of W. somnifera extracts. We present here an overview of the chemical structures of triterpenoid components and their biological activity, focusing on two novel activities, tumor inhibition and antiangiogenic properties of withaferin A and the effects of withanolide A on Alzheimer's disease. The most recent attempts in biotechnological production of withanolides are also discussed.
Keywords: Withania somnifera; withanolides; withaferin A; withanolide A; triterpenoids Withania somnifera; withanolides; withaferin A; withanolide A; triterpenoids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Mirjalili, M.H.; Moyano, E.; Bonfill, M.; Cusido, R.M.; Palazón, J. Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine. Molecules 2009, 14, 2373-2393.

AMA Style

Mirjalili MH, Moyano E, Bonfill M, Cusido RM, Palazón J. Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine. Molecules. 2009; 14(7):2373-2393.

Chicago/Turabian Style

Mirjalili, Mohammad H.; Moyano, Elisabeth; Bonfill, Mercedes; Cusido, Rosa M.; Palazón, Javier. 2009. "Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine." Molecules 14, no. 7: 2373-2393.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert