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New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity
Department of Medicinal Chemistry, Theodor Bilharz Research Institute, P.O.B. 12411, Giza, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, P.O.B. 11795, Ain-Helwan, Cairo, Egypt
* Author to whom correspondence should be addressed.
Received: 29 March 2009; in revised form: 8 May 2009 / Accepted: 13 May 2009 / Published: 25 May 2009
Abstract: From the leaves of Duranta repens (Verbenaceae) two new triterpene saponins, named durantanin IV (1) and V (2)were isolated.In addition, ten known compounds were isolated, namely a bidesmosidic saponin, oleanolic acid, three phenylethanoids and five flavonoids. All metabolites were isolated for the first time from this genus except for 3 (oleanolic acid) and 7 (E/Z acteoside). The structures were determined mainly by spectroscopic methods (UV, IR, HRESI-MS, 1H-, 13C-NMR, 1H-1H COSY, HSQC and HMBC). Cytotoxic screening of the chloroform, ethyl acetate and methanol extracts was carried out on brine shrimps. In addition, the investigated methanol extract and compounds 1, 2 and 7 showed significant cytotoxic activity against a HepG2 cell line.
Keywords: Duranta repens; triterpene saponins; durantanin IV and V; brine shrimp; HepG2
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MDPI and ACS Style
Ahmed, W.S.; Mohamed, M.A.; El-Dib, R.A.; Hamed, M.M. New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity. Molecules 2009, 14, 1952-1965.
Ahmed WS, Mohamed MA, El-Dib RA, Hamed MM. New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity. Molecules. 2009; 14(5):1952-1965.
Ahmed, Wafaa S.; Mohamed, Mona A.; El-Dib, Rabab A.; Hamed, Manal M. 2009. "New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity." Molecules 14, no. 5: 1952-1965.