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New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity
AbstractFrom the leaves of Duranta repens (Verbenaceae) two new triterpene saponins, named durantanin IV (1) and V (2)were isolated.In addition, ten known compounds were isolated, namely a bidesmosidic saponin, oleanolic acid, three phenylethanoids and five flavonoids. All metabolites were isolated for the first time from this genus except for 3 (oleanolic acid) and 7 (E/Z acteoside). The structures were determined mainly by spectroscopic methods (UV, IR, HRESI-MS, 1H-, 13C-NMR, 1H-1H COSY, HSQC and HMBC). Cytotoxic screening of the chloroform, ethyl acetate and methanol extracts was carried out on brine shrimps. In addition, the investigated methanol extract and compounds 1, 2 and 7 showed significant cytotoxic activity against a HepG2 cell line.
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Ahmed, W.S.; Mohamed, M.A.; El-Dib, R.A.; Hamed, M.M. New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity. Molecules 2009, 14, 1952-1965.View more citation formats
Ahmed WS, Mohamed MA, El-Dib RA, Hamed MM. New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity. Molecules. 2009; 14(5):1952-1965.Chicago/Turabian Style
Ahmed, Wafaa S.; Mohamed, Mona A.; El-Dib, Rabab A.; Hamed, Manal M. 2009. "New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity." Molecules 14, no. 5: 1952-1965.
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