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Molecules 2009, 14(5), 1952-1965; doi:10.3390/molecules14051952
Article

New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity

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Received: 29 March 2009 / Revised: 8 May 2009 / Accepted: 13 May 2009 / Published: 25 May 2009
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Abstract

From the leaves of Duranta repens (Verbenaceae) two new triterpene saponins, named durantanin IV (1) and V (2)were isolated.In addition, ten known compounds were isolated, namely a bidesmosidic saponin, oleanolic acid, three phenylethanoids and five flavonoids. All metabolites were isolated for the first time from this genus except for 3 (oleanolic acid) and 7 (E/Z acteoside). The structures were determined mainly by spectroscopic methods (UV, IR, HRESI-MS, 1H-, 13C-NMR, 1H-1H COSY, HSQC and HMBC). Cytotoxic screening of the chloroform, ethyl acetate and methanol extracts was carried out on brine shrimps. In addition, the investigated methanol extract and compounds 1, 2 and 7 showed significant cytotoxic activity against a HepG2 cell line.
Keywords: Duranta repens; triterpene saponins; durantanin IV and V; brine shrimp; HepG2 Duranta repens; triterpene saponins; durantanin IV and V; brine shrimp; HepG2
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Ahmed, W.S.; Mohamed, M.A.; El-Dib, R.A.; Hamed, M.M. New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity. Molecules 2009, 14, 1952-1965.

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