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Molecules 2009, 14(5), 1952-1965; doi:10.3390/molecules14051952
Article

New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity

1
, 1,* , 2
 and 1
Received: 29 March 2009; in revised form: 8 May 2009 / Accepted: 13 May 2009 / Published: 25 May 2009
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Abstract: From the leaves of Duranta repens (Verbenaceae) two new triterpene saponins, named durantanin IV (1) and V (2)were isolated.In addition, ten known compounds were isolated, namely a bidesmosidic saponin, oleanolic acid, three phenylethanoids and five flavonoids. All metabolites were isolated for the first time from this genus except for 3 (oleanolic acid) and 7 (E/Z acteoside). The structures were determined mainly by spectroscopic methods (UV, IR, HRESI-MS, 1H-, 13C-NMR, 1H-1H COSY, HSQC and HMBC). Cytotoxic screening of the chloroform, ethyl acetate and methanol extracts was carried out on brine shrimps. In addition, the investigated methanol extract and compounds 1, 2 and 7 showed significant cytotoxic activity against a HepG2 cell line.
Keywords: Duranta repens; triterpene saponins; durantanin IV and V; brine shrimp; HepG2 Duranta repens; triterpene saponins; durantanin IV and V; brine shrimp; HepG2
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ahmed, W.S.; Mohamed, M.A.; El-Dib, R.A.; Hamed, M.M. New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity. Molecules 2009, 14, 1952-1965.

AMA Style

Ahmed WS, Mohamed MA, El-Dib RA, Hamed MM. New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity. Molecules. 2009; 14(5):1952-1965.

Chicago/Turabian Style

Ahmed, Wafaa S.; Mohamed, Mona A.; El-Dib, Rabab A.; Hamed, Manal M. 2009. "New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity." Molecules 14, no. 5: 1952-1965.


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