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Molecules 2009, 14(5), 1889-1897; doi:10.3390/molecules14051889

Sesquiterpenes from Laurencia similis

1, 2
1, 1, 2, 1, 2, 1, 2, 1,*  and 1,*
1 Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China 2 Graduate School of the Chinese Academy of Sciences, Beijing 100049, China
* Authors to whom correspondence should be addressed.
Received: 17 March 2009 / Revised: 21 April 2009 / Accepted: 27 April 2009 / Published: 20 May 2009
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One new sesquiterpene, (4E)-1-bromo-5-[(1'S*,3'R*)-3'-bromo-2',2'-dimethyl-6'-methylenecyclohexyl]-3-methylpent-4-ene-2,3-diol (1), and fifteen known sesquiterpenes, isopalisol (2), luzonensol (3), palisadin B (4), aplysistatin (5), palisadin A (6), 4-hydroxyl-palisudin C (7), 5-acetoxypalisadin B (8), 10-hydroxyaristolan-9-one (9), aristol-8-en-1-one (10), aristolan-9-en-1-one (11), aristolan-1(10)-en-9-one (12), aristolan-1(10)-en-9-ol (13), aristolan-1(10),8-diene (14), aristolan-1,9-diene (15) and aristofone (16), were isolated from a sample of marine red alga Laurencia similis. Their structures were established by detailed NMR spectroscopic analysis and comparison with literature data. Compounds 2-9, and 16 were isolated for the first time from this species. All these metabolites were submitted for a cytotoxicity assay against the tumor cell line BEL7402 (human liver adenocarcinoma), but all of them were found inactive (IC50 > 10 μg/mL).
Keywords: Laurencia similis; sesquiterpenes; cytotoxic assay Laurencia similis; sesquiterpenes; cytotoxic assay
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Su, H.; Shi, D.-Y.; Li, J.; Guo, S.-J.; Li, L.-L.; Yuan, Z.-H.; Zhu, X.-B. Sesquiterpenes from Laurencia similis. Molecules 2009, 14, 1889-1897.

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