Abstract: One new sesquiterpene, (4E)-1-bromo-5-[(1'S*,3'R*)-3'-bromo-2',2'-dimethyl-6'-methylenecyclohexyl]-3-methylpent-4-ene-2,3-diol (1), and fifteen known sesquiterpenes, isopalisol (2), luzonensol (3), palisadin B (4), aplysistatin (5), palisadin A (6), 4-hydroxyl-palisudin C (7), 5-acetoxypalisadin B (8), 10-hydroxyaristolan-9-one (9), aristol-8-en-1-one (10), aristolan-9-en-1-one (11), aristolan-1(10)-en-9-one (12), aristolan-1(10)-en-9-ol (13), aristolan-1(10),8-diene (14), aristolan-1,9-diene (15) and aristofone (16), were isolated from a sample of marine red alga Laurencia similis. Their structures were established by detailed NMR spectroscopic analysis and comparison with literature data. Compounds 2-9, and 16 were isolated for the first time from this species. All these metabolites were submitted for a cytotoxicity assay against the tumor cell line BEL7402 (human liver adenocarcinoma), but all of them were found inactive (IC50 > 10 μg/mL).
Keywords: Laurencia similis; sesquiterpenes; cytotoxic assay
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Su, H.; Shi, D.-Y.; Li, J.; Guo, S.-J.; Li, L.-L.; Yuan, Z.-H.; Zhu, X.-B. Sesquiterpenes from Laurencia similis. Molecules 2009, 14, 1889-1897.
Su H, Shi D-Y, Li J, Guo S-J, Li L-L, Yuan Z-H, Zhu X-B. Sesquiterpenes from Laurencia similis. Molecules. 2009; 14(5):1889-1897.
Su, Hua; Shi, Da-Yong; Li, Jing; Guo, Shu-Ju; Li, Li-Li; Yuan, Zhao-Hui; Zhu, Xiao-Bin. 2009. "Sesquiterpenes from Laurencia similis." Molecules 14, no. 5: 1889-1897.