Sesquiterpenes from Laurencia similis

doi:10.3390/molecules14051889

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Molecules 2009, 14(5), 1889-1897; doi:10.3390/molecules14051889

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Sesquiterpenes from Laurencia similis

Hua Su^{1, 2}, Da-Yong Shi¹, Jing Li^{1, 2}, Shu-Ju Guo^{1, 2}, Li-Li Li^{1, 2}, Zhao-Hui Yuan^1,* and Xiao-Bin Zhu^1,*

¹ Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China ² Graduate School of the Chinese Academy of Sciences, Beijing 100049, China

* Authors to whom correspondence should be addressed.

Received: 17 March 2009; in revised form: 21 April 2009 / Accepted: 27 April 2009 / Published: 20 May 2009

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Abstract: One new sesquiterpene, (4E)-1-bromo-5-[(1'S*,3'R*)-3'-bromo-2',2'-dimethyl-6'-methylenecyclohexyl]-3-methylpent-4-ene-2,3-diol (1), and fifteen known sesquiterpenes, isopalisol (2), luzonensol (3), palisadin B (4), aplysistatin (5), palisadin A (6), 4-hydroxyl-palisudin C (7), 5-acetoxypalisadin B (8), 10-hydroxyaristolan-9-one (9), aristol-8-en-1-one (10), aristolan-9-en-1-one (11), aristolan-1(10)-en-9-one (12), aristolan-1(10)-en-9-ol (13), aristolan-1(10),8-diene (14), aristolan-1,9-diene (15) and aristofone (16), were isolated from a sample of marine red alga Laurencia similis. Their structures were established by detailed NMR spectroscopic analysis and comparison with literature data. Compounds 2-9, and 16 were isolated for the first time from this species. All these metabolites were submitted for a cytotoxicity assay against the tumor cell line BEL7402 (human liver adenocarcinoma), but all of them were found inactive (IC₅₀> 10 μg/mL).

Keywords: Laurencia similis; sesquiterpenes; cytotoxic assay

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Cite This Article

MDPI and ACS Style

Su, H.; Shi, D.-Y.; Li, J.; Guo, S.-J.; Li, L.-L.; Yuan, Z.-H.; Zhu, X.-B. Sesquiterpenes from Laurencia similis. Molecules 2009, 14, 1889-1897.

AMA Style

Su H, Shi D-Y, Li J, Guo S-J, Li L-L, Yuan Z-H, Zhu X-B. Sesquiterpenes from Laurencia similis. Molecules. 2009; 14(5):1889-1897.

Chicago/Turabian Style

Su, Hua; Shi, Da-Yong; Li, Jing; Guo, Shu-Ju; Li, Li-Li; Yuan, Zhao-Hui; Zhu, Xiao-Bin. 2009. "Sesquiterpenes from Laurencia similis." Molecules 14, no. 5: 1889-1897.

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