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Molecules 2009, 14(5), 1889-1897; doi:10.3390/molecules14051889
Article

Sesquiterpenes from Laurencia similis

1, 2
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1, 1, 2, 1, 2, 1, 2, 1,*  and 1,*
Received: 17 March 2009 / Revised: 21 April 2009 / Accepted: 27 April 2009 / Published: 20 May 2009
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Abstract

One new sesquiterpene, (4E)-1-bromo-5-[(1'S*,3'R*)-3'-bromo-2',2'-dimethyl-6'-methylenecyclohexyl]-3-methylpent-4-ene-2,3-diol (1), and fifteen known sesquiterpenes, isopalisol (2), luzonensol (3), palisadin B (4), aplysistatin (5), palisadin A (6), 4-hydroxyl-palisudin C (7), 5-acetoxypalisadin B (8), 10-hydroxyaristolan-9-one (9), aristol-8-en-1-one (10), aristolan-9-en-1-one (11), aristolan-1(10)-en-9-one (12), aristolan-1(10)-en-9-ol (13), aristolan-1(10),8-diene (14), aristolan-1,9-diene (15) and aristofone (16), were isolated from a sample of marine red alga Laurencia similis. Their structures were established by detailed NMR spectroscopic analysis and comparison with literature data. Compounds 2-9, and 16 were isolated for the first time from this species. All these metabolites were submitted for a cytotoxicity assay against the tumor cell line BEL7402 (human liver adenocarcinoma), but all of them were found inactive (IC50 > 10 μg/mL).
Keywords: Laurencia similis; sesquiterpenes; cytotoxic assay Laurencia similis; sesquiterpenes; cytotoxic assay
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Su, H.; Shi, D.-Y.; Li, J.; Guo, S.-J.; Li, L.-L.; Yuan, Z.-H.; Zhu, X.-B. Sesquiterpenes from Laurencia similis. Molecules 2009, 14, 1889-1897.

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