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Molecules 2009, 14(5), 1898-1903; doi:10.3390/molecules14051898
Communication

Synthesis and Antimicrobial Evaluation of Some New Oxadiazoles Derived from Phenylpropionohydrazides

1,* , 1
, 2
 and 3
Received: 14 April 2009; in revised form: 12 May 2009 / Accepted: 13 May 2009 / Published: 20 May 2009
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Abstract: In this study a series ofnew1-(2-aryl-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanones 2a-e was synthesized by the cyclization of imines 1a-e using acetic anhydride. The products were evaluated for anti-bacterial and anti-fungal activity. Among the newly synthesized compounds, 1-(2-(4-(dimethylamino)phenyl)-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanone (2a)and1-(2-(4-chlorophenyl)-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanone (2b)were found to possess maximum activity against the tested strains of S. aureus and P. aeruginosa. It was concluded that para-substitution enhances the activity of synthesized oxadiazoles.
Keywords: phenylpropionohydrazide; imines; oxadiazoles; antibacterial; antifungal phenylpropionohydrazide; imines; oxadiazoles; antibacterial; antifungal
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Fuloria, N.K.; Singh, V.; Shaharyar, M.; Ali, M. Synthesis and Antimicrobial Evaluation of Some New Oxadiazoles Derived from Phenylpropionohydrazides. Molecules 2009, 14, 1898-1903.

AMA Style

Fuloria NK, Singh V, Shaharyar M, Ali M. Synthesis and Antimicrobial Evaluation of Some New Oxadiazoles Derived from Phenylpropionohydrazides. Molecules. 2009; 14(5):1898-1903.

Chicago/Turabian Style

Fuloria, Neeraj Kumar; Singh, Vijender; Shaharyar, Mohammad; Ali, Mohammad. 2009. "Synthesis and Antimicrobial Evaluation of Some New Oxadiazoles Derived from Phenylpropionohydrazides." Molecules 14, no. 5: 1898-1903.


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