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Molecules 2009, 14(5), 1898-1903; https://doi.org/10.3390/molecules14051898

Synthesis and Antimicrobial Evaluation of Some New Oxadiazoles Derived from Phenylpropionohydrazides

1
Department of Pharmacy, Rameesh Institute of Vocational and Technical Education, 3-Knowledge Park-1, Kasna road, Greater NOIDA, India
2
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi-110062, India
3
Department of Pharmacognosy & Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi-110062, India
*
Author to whom correspondence should be addressed.
Received: 14 April 2009 / Revised: 12 May 2009 / Accepted: 13 May 2009 / Published: 20 May 2009
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Abstract

In this study a series ofnew1-(2-aryl-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanones 2a-e was synthesized by the cyclization of imines 1a-e using acetic anhydride. The products were evaluated for anti-bacterial and anti-fungal activity. Among the newly synthesized compounds, 1-(2-(4-(dimethylamino)phenyl)-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanone (2a)and1-(2-(4-chlorophenyl)-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanone (2b)were found to possess maximum activity against the tested strains of S. aureus and P. aeruginosa. It was concluded that para-substitution enhances the activity of synthesized oxadiazoles.
Keywords: phenylpropionohydrazide; imines; oxadiazoles; antibacterial; antifungal phenylpropionohydrazide; imines; oxadiazoles; antibacterial; antifungal
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Fuloria, N.K.; Singh, V.; Shaharyar, M.; Ali, M. Synthesis and Antimicrobial Evaluation of Some New Oxadiazoles Derived from Phenylpropionohydrazides. Molecules 2009, 14, 1898-1903.

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