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Molecules 2009, 14(5), 1860-1868; doi:10.3390/molecules14051860
Article

Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations

1, 2,* , 1, 3, 1 and 3
Received: 16 March 2009; in revised form: 6 April 2009 / Accepted: 9 April 2009 / Published: 20 May 2009
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Abstract: Alkylation is a very important chemical reaction which modifies the biological properties of drugs. Quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties.We now report application of a practical alkylation procedure to several quinazolinediones, including pelanserine (5f), which shows antihypertensive properties, 1-methyl-3-(2'-phenylethyl)-1H,3H-quinazoline-2,4-dione (1ab) and 1-methyl-3-[2'-(4'-methoxyphenyl)ethyl]-lH,3H-quinazoline-2,4-dione (1ae), which had been isolated from natural sources. The alkylation was optimized using dimethyl and diethyl carbonates under microwave irradiations.
Keywords: alkylation; quinazoline-2; 4-dione; antihypertensive activity; microwaves alkylation; quinazoline-2; 4-dione; antihypertensive activity; microwaves
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Rivero, I.A.; Guerrero, L.; Espinoza, K.A.; Meza, M.C.; Rodríguez, J.R. Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations. Molecules 2009, 14, 1860-1868.

AMA Style

Rivero IA, Guerrero L, Espinoza KA, Meza MC, Rodríguez JR. Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations. Molecules. 2009; 14(5):1860-1868.

Chicago/Turabian Style

Rivero, Ignacio Alfredo; Guerrero, Leticia; Espinoza, Karla Alejandra; Meza, Martha Cecilia; Rodríguez, Jesús Ramón. 2009. "Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations." Molecules 14, no. 5: 1860-1868.


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