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Molecules 2009, 14(5), 1818-1824; doi:10.3390/molecules14051818

Phenoxypropylamines: Synthesis and Antiulcer Evaluation

1
College of Sciences, Northeastern University, Shenyang 110004, China
2
Department of Chemistry, Shenyang Medical College, Shenyang 110034, China
3
School of Public Health, China Medical University, Shenyang 110001, China
4
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China
5
School of Medicinal Application & Technology, Shenyang Medical College, Shenyang 110034, China
*
Author to whom correspondence should be addressed.
Received: 9 April 2009 / Accepted: 8 May 2009 / Published: 13 May 2009
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Abstract

We have synthesized a number of phenoxypropylamines from N-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}chloroacetamide (3). All the products have been characterized by elemental analysis, 1H-NMR and MS. The biological activity effects of the title compounds were examined. From the biological activity results, we found that two of themshowed significant gastric acid antisecretory activity. View Full-Text
Keywords: roxatidine; synthesis; antiulcer agents; phenoxypropylamine; biological activity roxatidine; synthesis; antiulcer agents; phenoxypropylamine; biological activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhang, H.; Zhang, B.-Y.; Zhang, Q.-Y.; Zhao, D.-M.; Wang, J.-M. Phenoxypropylamines: Synthesis and Antiulcer Evaluation. Molecules 2009, 14, 1818-1824.

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