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Molecules 2009, 14(5), 1818-1824; doi:10.3390/molecules14051818

Phenoxypropylamines: Synthesis and Antiulcer Evaluation

1, 2,* , 1
1 College of Sciences, Northeastern University, Shenyang 110004, China 2 Department of Chemistry, Shenyang Medical College, Shenyang 110034, China 3 School of Public Health, China Medical University, Shenyang 110001, China 4 School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China 5 School of Medicinal Application & Technology, Shenyang Medical College, Shenyang 110034, China
* Author to whom correspondence should be addressed.
Received: 9 April 2009 / Accepted: 8 May 2009 / Published: 13 May 2009
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We have synthesized a number of phenoxypropylamines from N-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}chloroacetamide (3). All the products have been characterized by elemental analysis, 1H-NMR and MS. The biological activity effects of the title compounds were examined. From the biological activity results, we found that two of themshowed significant gastric acid antisecretory activity.
Keywords: roxatidine; synthesis; antiulcer agents; phenoxypropylamine; biological activity roxatidine; synthesis; antiulcer agents; phenoxypropylamine; biological activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhang, H.; Zhang, B.-Y.; Zhang, Q.-Y.; Zhao, D.-M.; Wang, J.-M. Phenoxypropylamines: Synthesis and Antiulcer Evaluation. Molecules 2009, 14, 1818-1824.

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