Molecules 2009, 14(5), 1818-1824; doi:10.3390/molecules14051818
Article

Phenoxypropylamines: Synthesis and Antiulcer Evaluation

Hui Zhang 1, 2,* email, Bao-Yan Zhang 1 email, Qian-Yun Zhang 3 email, Dong-Mei Zhao 4 email and Jia-Mei Wang 5 email
1 College of Sciences, Northeastern University, Shenyang 110004, China 2 Department of Chemistry, Shenyang Medical College, Shenyang 110034, China 3 School of Public Health, China Medical University, Shenyang 110001, China 4 School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China 5 School of Medicinal Application & Technology, Shenyang Medical College, Shenyang 110034, China
* Author to whom correspondence should be addressed.
Received: 9 April 2009 / Accepted: 8 May 2009 / Published: 13 May 2009
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Abstract: We have synthesized a number of phenoxypropylamines from N-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}chloroacetamide (3). All the products have been characterized by elemental analysis, 1H-NMR and MS. The biological activity effects of the title compounds were examined. From the biological activity results, we found that two of themshowed significant gastric acid antisecretory activity.
Keywords: roxatidine; synthesis; antiulcer agents; phenoxypropylamine; biological activity

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Cite This Article

MDPI and ACS Style

Zhang, H.; Zhang, B.-Y.; Zhang, Q.-Y.; Zhao, D.-M.; Wang, J.-M. Phenoxypropylamines: Synthesis and Antiulcer Evaluation. Molecules 2009, 14, 1818-1824.

AMA Style

Zhang H, Zhang B-Y, Zhang Q-Y, Zhao D-M, Wang J-M. Phenoxypropylamines: Synthesis and Antiulcer Evaluation. Molecules. 2009; 14(5):1818-1824.

Chicago/Turabian Style

Zhang, Hui; Zhang, Bao-Yan; Zhang, Qian-Yun; Zhao, Dong-Mei; Wang, Jia-Mei. 2009. "Phenoxypropylamines: Synthesis and Antiulcer Evaluation." Molecules 14, no. 5: 1818-1824.

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