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Molecules 2009, 14(5), 1789-1795; doi:10.3390/molecules14051789
Article

Isolation and Immunomodulatory Effect of Homoisoflavones and Flavones from Agave sisalana Perrine ex Engelm.

1
, 2
, 1
, 3, 4,*  and 1,*
1 Graduate Institute of Pharmacy, Taipei Medical University, 250 Wu Xin Street, Taipei 11031, Taiwan 2 Institute of Life Science, Fu-Jen University; 510 Chung Cheng Rd, Hsinchuang, Taipei 24205, Taiwan 3 Tsutzki Institute for Traditional Medicine, China Medical University, 91 Hsueh Shih Road, Taichung 40402, Taiwan 4 Agricultural Biotechnology Research Center, Academia Sinica, 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan
* Authors to whom correspondence should be addressed.
Received: 2 April 2009 / Revised: 29 April 2009 / Accepted: 30 April 2009 / Published: 12 May 2009
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Abstract

Three known flavones and seven known homoisoflavonoids were isolated from the methanolic extract of the leaves of Agave sisalanaPerrine ex Engelm. Their structures were elucidated on the basis of spectroscopic analysis. The isolated compounds were also evaluated for immunopharmacological activity. PBMC were used as target cells, and cell proliferation was determined by 3H-thymidine uptake. (±)-3,9-Dihydroeucomin (4), dihydrobonducellin (5), and 5,7-dihydroxy-3-(4′-hydroxybenzyl)-4-chromanone (7) showed inhibitory effects on PBMC proliferation activated by PHA with IC50 values 19.4, 73.8, and 58.8 µM, respectively. All three compounds significantly inhibited the production of IL-2 and IFN-γ in activated PBMC in a concentration-dependent manner.
Keywords: Agave sisalana Perrine ex Engelm.; homoisoflavonoid; PBMC; IL-2; IFN-γ Agave sisalana Perrine ex Engelm.; homoisoflavonoid; PBMC; IL-2; IFN-γ
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, P.Y.; Kuo, Y.C.; Chen, C.H.; Kuo, Y.H.; Lee, C.K. Isolation and Immunomodulatory Effect of Homoisoflavones and Flavones from Agave sisalana Perrine ex Engelm.. Molecules 2009, 14, 1789-1795.

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