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Molecules 2009, 14(5), 1789-1795; doi:10.3390/molecules14051789
Article

Isolation and Immunomodulatory Effect of Homoisoflavones and Flavones from Agave sisalana Perrine ex Engelm.

1
, 2
, 1
, 3, 4,*  and 1,*
Received: 2 April 2009; in revised form: 29 April 2009 / Accepted: 30 April 2009 / Published: 12 May 2009
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Abstract: Three known flavones and seven known homoisoflavonoids were isolated from the methanolic extract of the leaves of Agave sisalanaPerrine ex Engelm. Their structures were elucidated on the basis of spectroscopic analysis. The isolated compounds were also evaluated for immunopharmacological activity. PBMC were used as target cells, and cell proliferation was determined by 3H-thymidine uptake. (±)-3,9-Dihydroeucomin (4), dihydrobonducellin (5), and 5,7-dihydroxy-3-(4′-hydroxybenzyl)-4-chromanone (7) showed inhibitory effects on PBMC proliferation activated by PHA with IC50 values 19.4, 73.8, and 58.8 µM, respectively. All three compounds significantly inhibited the production of IL-2 and IFN-γ in activated PBMC in a concentration-dependent manner.
Keywords: Agave sisalana Perrine ex Engelm.; homoisoflavonoid; PBMC; IL-2; IFN-γ Agave sisalana Perrine ex Engelm.; homoisoflavonoid; PBMC; IL-2; IFN-γ
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, P.Y.; Kuo, Y.C.; Chen, C.H.; Kuo, Y.H.; Lee, C.K. Isolation and Immunomodulatory Effect of Homoisoflavones and Flavones from Agave sisalana Perrine ex Engelm.. Molecules 2009, 14, 1789-1795.

AMA Style

Chen PY, Kuo YC, Chen CH, Kuo YH, Lee CK. Isolation and Immunomodulatory Effect of Homoisoflavones and Flavones from Agave sisalana Perrine ex Engelm.. Molecules. 2009; 14(5):1789-1795.

Chicago/Turabian Style

Chen, Pi Yu; Kuo, Yuh Chi; Chen, Chin Hui; Kuo, Yueh Hsiung; Lee, Ching Kuo. 2009. "Isolation and Immunomodulatory Effect of Homoisoflavones and Flavones from Agave sisalana Perrine ex Engelm.." Molecules 14, no. 5: 1789-1795.



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