Molecules 2009, 14(4), 1456-1467; doi:10.3390/molecules14041456
Article

Polyphenolic Profile and Bioactivity Study of Oenothera speciosa Nutt. Aerial Parts

1 Natural Products Group, Centre of Scientific Excellence, National Research Center, El-Behoos St. 31, Dokki, Cairo, Egypt 2 Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Cairo, Egypt 3 Department of Pharmacology, National Research Center, El-Behoos St.31, Dokki, Cairo, Egypt
* Author to whom correspondence should be addressed.
Received: 10 February 2009; in revised form: 19 March 2009 / Accepted: 26 March 2009 / Published: 7 April 2009
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Abstract: Two new flavonol glycosides, myricetin 4'-O-α-L-rhamnopyranoside (1) and quercetin 3'-O-α-L-rhamnopyranoside (2), together with a novel biflavonol compound, speciin (3), as well as eleven phenolic metabolites, namely myricitrin (4), europetin 3-O-α-L-1C4-rhamnopyranoside (5), quercitrin (6), hyperin (7), rhamnetin 3-O-β-galacto-pyranoside (8), caffeic acid (9), caffeic acid methyl ester (10), chlorogenic acid (11), chlorogenic acid methyl ester (12), gallic acid (13) and gallic acid methyl ester (14), were identified from the 80 % methanol extract of the aerial parts (leaves and stems) of Oenothera speciosa Nutt. (Onagraceae). In addition myricetin (15), quercetin (16) and ellagic acid (17) were identified from the chloroform extract. The structures were established depending on their chemical and physical analyses (UV, HR-ESIMS, 1D and 2D NMR). It was found that 80 % aqueous methanol extract of O. speciosa is non-toxic to mice up to 5 g kg-1b.wt. The investigated extract exhibited significant antihyperglycaemic and anti-inflammatory activities in a dose dependant manner. Also, the 80 % methanol extract, myricitrin(4) and hyperin(7) showed potent antioxidant activity in vitro using 1,1-diphenyl 2-picryl hydrazyl (DPPH) radical assay.
Keywords: Oenothera speciosa; Biflavonol; Antihyperglycaemic; Anti-inflammatory; Antioxidant

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MDPI and ACS Style

Marzouk, M.S.; Moharram, F.A.; El Dib, R.A.; El-Shenawy, S.M.; Tawfike, A.F. Polyphenolic Profile and Bioactivity Study of Oenothera speciosa Nutt. Aerial Parts. Molecules 2009, 14, 1456-1467.

AMA Style

Marzouk MS, Moharram FA, El Dib RA, El-Shenawy SM, Tawfike AF. Polyphenolic Profile and Bioactivity Study of Oenothera speciosa Nutt. Aerial Parts. Molecules. 2009; 14(4):1456-1467.

Chicago/Turabian Style

Marzouk, Mohamed S.; Moharram, Fatma A.; El Dib, Rabab A.; El-Shenawy, Siham M.; Tawfike, Ahmed F. 2009. "Polyphenolic Profile and Bioactivity Study of Oenothera speciosa Nutt. Aerial Parts." Molecules 14, no. 4: 1456-1467.

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