Next Article in Journal
Synthesis of Novel Hybrid Molecules from Precursors With Known Antiparasitic Activity
Previous Article in Journal
An Efficient One-Pot Three-Component Synthesis of Fused 1,4-Dihydropyridines Using HY-Zeolit
Article Menu

Export Article

Open AccessArticle
Molecules 2009, 14(4), 1456-1467; doi:10.3390/molecules14041456

Polyphenolic Profile and Bioactivity Study of Oenothera speciosa Nutt. Aerial Parts

Natural Products Group, Centre of Scientific Excellence, National Research Center, El-Behoos St. 31, Dokki, Cairo, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Cairo, Egypt
Department of Pharmacology, National Research Center, El-Behoos St.31, Dokki, Cairo, Egypt
Author to whom correspondence should be addressed.
Received: 10 February 2009 / Revised: 19 March 2009 / Accepted: 26 March 2009 / Published: 7 April 2009
View Full-Text   |   Download PDF [194 KB, uploaded 18 June 2014]   |  


Two new flavonol glycosides, myricetin 4'-O-α-L-rhamnopyranoside (1) and quercetin 3'-O-α-L-rhamnopyranoside (2), together with a novel biflavonol compound, speciin (3), as well as eleven phenolic metabolites, namely myricitrin (4), europetin 3-O-α-L-1C4-rhamnopyranoside (5), quercitrin (6), hyperin (7), rhamnetin 3-O-β-galacto-pyranoside (8), caffeic acid (9), caffeic acid methyl ester (10), chlorogenic acid (11), chlorogenic acid methyl ester (12), gallic acid (13) and gallic acid methyl ester (14), were identified from the 80 % methanol extract of the aerial parts (leaves and stems) of Oenothera speciosa Nutt. (Onagraceae). In addition myricetin (15), quercetin (16) and ellagic acid (17) were identified from the chloroform extract. The structures were established depending on their chemical and physical analyses (UV, HR-ESIMS, 1D and 2D NMR). It was found that 80 % aqueous methanol extract of O. speciosa is non-toxic to mice up to 5 g kg-1b.wt. The investigated extract exhibited significant antihyperglycaemic and anti-inflammatory activities in a dose dependant manner. Also, the 80 % methanol extract, myricitrin(4) and hyperin(7) showed potent antioxidant activity in vitro using 1,1-diphenyl 2-picryl hydrazyl (DPPH) radical assay.
Keywords: Oenothera speciosa; Biflavonol; Antihyperglycaemic; Anti-inflammatory; Antioxidant Oenothera speciosa; Biflavonol; Antihyperglycaemic; Anti-inflammatory; Antioxidant
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Marzouk, M.S.; Moharram, F.A.; El Dib, R.A.; El-Shenawy, S.M.; Tawfike, A.F. Polyphenolic Profile and Bioactivity Study of Oenothera speciosa Nutt. Aerial Parts. Molecules 2009, 14, 1456-1467.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top