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Molecules 2009, 14(3), 1056-1061; doi:10.3390/molecules14031056
Article

Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water

*  and
School of Chemistry, University College of Science, University of Tehran, Tehran, Iran
* Author to whom correspondence should be addressed.
Received: 11 February 2009 / Revised: 25 February 2009 / Accepted: 3 March 2009 / Published: 5 March 2009
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Abstract

The three component reaction of primary aliphatic amines, glyoxalic acid and indole or N-methylindole in water at ambient temperature affords indol-3-yl or N-methylindol-3-yl-glycine in almost quantitative yields.
Keywords: Amino acid; Indol-3-yl-glycine; Glyoxalic acid; Friedel-Crafts reaction Amino acid; Indol-3-yl-glycine; Glyoxalic acid; Friedel-Crafts reaction
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Ghandi, M.; Taheri, A. Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water. Molecules 2009, 14, 1056-1061.

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