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Molecules 2009, 14(3), 1056-1061; doi:10.3390/molecules14031056
Article

Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water

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Received: 11 February 2009; in revised form: 25 February 2009 / Accepted: 3 March 2009 / Published: 5 March 2009
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Abstract: The three component reaction of primary aliphatic amines, glyoxalic acid and indole or N-methylindole in water at ambient temperature affords indol-3-yl or N-methylindol-3-yl-glycine in almost quantitative yields.
Keywords: Amino acid; Indol-3-yl-glycine; Glyoxalic acid; Friedel-Crafts reaction Amino acid; Indol-3-yl-glycine; Glyoxalic acid; Friedel-Crafts reaction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ghandi, M.; Taheri, A. Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water. Molecules 2009, 14, 1056-1061.

AMA Style

Ghandi M, Taheri A. Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water. Molecules. 2009; 14(3):1056-1061.

Chicago/Turabian Style

Ghandi, Mehdi; Taheri, Abuzar. 2009. "Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water." Molecules 14, no. 3: 1056-1061.


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