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Molecules 2009, 14(3), 1056-1061; doi:10.3390/molecules14031056

Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water

School of Chemistry, University College of Science, University of Tehran, Tehran, Iran
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Received: 11 February 2009 / Revised: 25 February 2009 / Accepted: 3 March 2009 / Published: 5 March 2009
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Abstract

The three component reaction of primary aliphatic amines, glyoxalic acid and indole or N-methylindole in water at ambient temperature affords indol-3-yl or N-methylindol-3-yl-glycine in almost quantitative yields. View Full-Text
Keywords: Amino acid; Indol-3-yl-glycine; Glyoxalic acid; Friedel-Crafts reaction Amino acid; Indol-3-yl-glycine; Glyoxalic acid; Friedel-Crafts reaction
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Ghandi, M.; Taheri, A. Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water. Molecules 2009, 14, 1056-1061.

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