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Molecules 2009, 14(2), 763-770; doi:10.3390/molecules14020763
Article

Copper(II) Sulfamate: An Efficient Catalyst for the One-Pot Synthesis of 3,4-Dihydropyrimidine-2(1H)-ones and thiones

1,2
 and
1,2,*
1 School of Science, Xi'an Jiaotong University, 710049 Xi'an, P. R. China 2 School of Chemistry and Chemical Engineering, Xinjiang University, Key Laboratory of Oil and Gas Fine Chemicals, Ministry of Education, 830046 Urumqi, P. R. China
* Author to whom correspondence should be addressed.
Received: 11 January 2009 / Revised: 6 February 2009 / Accepted: 11 February 2009 / Published: 13 February 2009
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Abstract

A simple, efficient procedure for the one-pot Biginelli condensation reaction of aldehydes, β-ketoesters and urea or thiourea employing copper(II) sulfamate as a novel catalyst is described. Compared to the classical Biginelli reaction conditions, the present method has the advantages of good yields, short reaction times and experimental simplicity.
Keywords: Copper(II) sulfamate; Biginelli reaction; Dihydropyrimidinones Copper(II) sulfamate; Biginelli reaction; Dihydropyrimidinones
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Liu, C.-J.; Wang, J.-D. Copper(II) Sulfamate: An Efficient Catalyst for the One-Pot Synthesis of 3,4-Dihydropyrimidine-2(1H)-ones and thiones. Molecules 2009, 14, 763-770.

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