Molecules 2009, 14(2), 755-762; doi:10.3390/molecules14020755

Properties of an Oral Preparation Containing a Chitosan Salt

* email, email, , email and
Received: 18 November 2008; in revised form: 11 February 2009 / Accepted: 13 February 2009 / Published: 13 February 2009
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The 2-(4-chlorophenoxy)-2-methylpropionic acid (CMP) salt of chitosan (CS), CS-CMP, and that of a CS derivative (CP), were prepared and their ability to adsorb bile acids investigated. CS-CMP and CP-CMP rapidly adsorbed taurocholate (TCA) and glycocholate (GCA) when these bile acids were present together in the medium, with simultaneous release of CMP. A secondary bile acid, taurodeoxycholate, was preferentially adsorbed over TCA and GCA. Alginate gel beads containing CS-CMP did not differ from CS-CMP alone in their manner of bile acids take up. Furthermore, oral administration of CS-CMP to rats resulted in decreased serum cholesterol and triacylglycerol levels for two weeks. Therefore, CS-CMP, as well as a vehiclecontaining CS-CMP, might be a useful agent with which to treat hyperlipidemia
Keywords: Chitosan; 2-(4-Chlorophenoxy)-2-methylpropionic acid; Bile acid adsorption; Drug release; Hyperlipidemia
PDF Full-text Download PDF Full-Text [80 KB, uploaded 18 June 2014 19:29 CEST]

Export to BibTeX |

MDPI and ACS Style

Murata, Y.; Kodama, Y.; Hirai, D.; Kofuji, K.; Kawashima, S. Properties of an Oral Preparation Containing a Chitosan Salt. Molecules 2009, 14, 755-762.

AMA Style

Murata Y, Kodama Y, Hirai D, Kofuji K, Kawashima S. Properties of an Oral Preparation Containing a Chitosan Salt. Molecules. 2009; 14(2):755-762.

Chicago/Turabian Style

Murata, Yoshifumi; Kodama, Youko; Hirai, Daijirou; Kofuji, Kyouko; Kawashima, Susumu. 2009. "Properties of an Oral Preparation Containing a Chitosan Salt." Molecules 14, no. 2: 755-762.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert