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Molecules 2009, 14(2), 755-762; doi:10.3390/molecules14020755
Communication

Properties of an Oral Preparation Containing a Chitosan Salt

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Faculty of Pharmaceutical Science, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan
* Author to whom correspondence should be addressed.
Received: 18 November 2008 / Revised: 11 February 2009 / Accepted: 13 February 2009 / Published: 13 February 2009
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Abstract

The 2-(4-chlorophenoxy)-2-methylpropionic acid (CMP) salt of chitosan (CS), CS-CMP, and that of a CS derivative (CP), were prepared and their ability to adsorb bile acids investigated. CS-CMP and CP-CMP rapidly adsorbed taurocholate (TCA) and glycocholate (GCA) when these bile acids were present together in the medium, with simultaneous release of CMP. A secondary bile acid, taurodeoxycholate, was preferentially adsorbed over TCA and GCA. Alginate gel beads containing CS-CMP did not differ from CS-CMP alone in their manner of bile acids take up. Furthermore, oral administration of CS-CMP to rats resulted in decreased serum cholesterol and triacylglycerol levels for two weeks. Therefore, CS-CMP, as well as a vehiclecontaining CS-CMP, might be a useful agent with which to treat hyperlipidemia
Keywords: Chitosan; 2-(4-Chlorophenoxy)-2-methylpropionic acid; Bile acid adsorption; Drug release; Hyperlipidemia Chitosan; 2-(4-Chlorophenoxy)-2-methylpropionic acid; Bile acid adsorption; Drug release; Hyperlipidemia
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Murata, Y.; Kodama, Y.; Hirai, D.; Kofuji, K.; Kawashima, S. Properties of an Oral Preparation Containing a Chitosan Salt. Molecules 2009, 14, 755-762.

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