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Properties of an Oral Preparation Containing a Chitosan Salt
AbstractThe 2-(4-chlorophenoxy)-2-methylpropionic acid (CMP) salt of chitosan (CS), CS-CMP, and that of a CS derivative (CP), were prepared and their ability to adsorb bile acids investigated. CS-CMP and CP-CMP rapidly adsorbed taurocholate (TCA) and glycocholate (GCA) when these bile acids were present together in the medium, with simultaneous release of CMP. A secondary bile acid, taurodeoxycholate, was preferentially adsorbed over TCA and GCA. Alginate gel beads containing CS-CMP did not differ from CS-CMP alone in their manner of bile acids take up. Furthermore, oral administration of CS-CMP to rats resulted in decreased serum cholesterol and triacylglycerol levels for two weeks. Therefore, CS-CMP, as well as a vehiclecontaining CS-CMP, might be a useful agent with which to treat hyperlipidemia
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Murata, Y.; Kodama, Y.; Hirai, D.; Kofuji, K.; Kawashima, S. Properties of an Oral Preparation Containing a Chitosan Salt. Molecules 2009, 14, 755-762.View more citation formats
Murata Y, Kodama Y, Hirai D, Kofuji K, Kawashima S. Properties of an Oral Preparation Containing a Chitosan Salt. Molecules. 2009; 14(2):755-762.Chicago/Turabian Style
Murata, Yoshifumi; Kodama, Youko; Hirai, Daijirou; Kofuji, Kyouko; Kawashima, Susumu. 2009. "Properties of an Oral Preparation Containing a Chitosan Salt." Molecules 14, no. 2: 755-762.
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