Molecules 2009, 14(2), 633-654; doi:10.3390/molecules14020633
Review

Prodrugs of Thyrotropin-Releasing Hormone and Related Peptides as Central Nervous System Agents

Katalin Prokai-Tatrai 1,* email and Laszlo Prokai 2 email
1 Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA 2 Department of Molecular Biology & Immunology, University of North Texas Health Science Center, Fort Worth, TX, USA
* Author to whom correspondence should be addressed.
Received: 1 January 2009; in revised form: 21 January 2009 / Accepted: 5 February 2009 / Published: 6 February 2009
(This article belongs to the Special Issue Prodrugs)
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Abstract: Prodrug design for brain delivery of small- and medium-sized neuropeptides was reviewed, focusing on thyrotropin-releasing hormone and structurally related peptides as examples. We have summarized our most important advances in methodology, as well as assessed the benefits and limitations of bioreversible chemical manipulation techniques to achieve targeting of the parent molecules into the central nervous system. The value of prodrug-amenable analogues as potential drug-like central nervous systems agents was highlighted.
Keywords: Neuropeptide; CNS-delivery; TRH; Analogue; Prodrug; Prodrug-amenable analogue

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Cite This Article

MDPI and ACS Style

Prokai-Tatrai, K.; Prokai, L. Prodrugs of Thyrotropin-Releasing Hormone and Related Peptides as Central Nervous System Agents. Molecules 2009, 14, 633-654.

AMA Style

Prokai-Tatrai K, Prokai L. Prodrugs of Thyrotropin-Releasing Hormone and Related Peptides as Central Nervous System Agents. Molecules. 2009; 14(2):633-654.

Chicago/Turabian Style

Prokai-Tatrai, Katalin; Prokai, Laszlo. 2009. "Prodrugs of Thyrotropin-Releasing Hormone and Related Peptides as Central Nervous System Agents." Molecules 14, no. 2: 633-654.

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