Molecules 2009, 14(2), 633-654; doi:10.3390/molecules14020633
Review

Prodrugs of Thyrotropin-Releasing Hormone and Related Peptides as Central Nervous System Agents

1,* email and 2email
Received: 1 January 2009; in revised form: 21 January 2009 / Accepted: 5 February 2009 / Published: 6 February 2009
(This article belongs to the collection Prodrugs)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Prodrug design for brain delivery of small- and medium-sized neuropeptides was reviewed, focusing on thyrotropin-releasing hormone and structurally related peptides as examples. We have summarized our most important advances in methodology, as well as assessed the benefits and limitations of bioreversible chemical manipulation techniques to achieve targeting of the parent molecules into the central nervous system. The value of prodrug-amenable analogues as potential drug-like central nervous systems agents was highlighted.
Keywords: Neuropeptide; CNS-delivery; TRH; Analogue; Prodrug; Prodrug-amenable analogue
PDF Full-text Download PDF Full-Text [209 KB, uploaded 18 June 2014 19:29 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Prokai-Tatrai, K.; Prokai, L. Prodrugs of Thyrotropin-Releasing Hormone and Related Peptides as Central Nervous System Agents. Molecules 2009, 14, 633-654.

AMA Style

Prokai-Tatrai K, Prokai L. Prodrugs of Thyrotropin-Releasing Hormone and Related Peptides as Central Nervous System Agents. Molecules. 2009; 14(2):633-654.

Chicago/Turabian Style

Prokai-Tatrai, Katalin; Prokai, Laszlo. 2009. "Prodrugs of Thyrotropin-Releasing Hormone and Related Peptides as Central Nervous System Agents." Molecules 14, no. 2: 633-654.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert