Next Article in Journal
Correlation between Antioxidant Activities and Phenolic Contents of Radix Angelicae Sinensis (Danggui)
Previous Article in Journal
Chemical Constituents from the Stems of Diospyros maritima
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2009, 14(12), 5339-5348; doi:10.3390/molecules14125339

Synthesis and Biological Evaluation of Novel 1-Alkyltryptophan Analogs as Potential Antitumor Agents

Department of Nuclear Medicine, Peking Union Medical College & Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing 100730, China
Department of Chemistry, Tsinghua University, Beijing 100084, China
Department of Pathology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Author to whom correspondence should be addressed.
Received: 28 November 2009 / Revised: 16 December 2009 / Accepted: 17 December 2009 / Published: 18 December 2009
Download PDF [498 KB, uploaded 18 June 2014]


To seek novel antitumor agents, we designed and synthesized new 1-tryptophan analogs based on tryptophan catabolism. 1-Alkyltryptophan analogues including 1-ethyltryptophan (1-ET), 1-propyltryptophan (1-PT), 1-isopropyltryptophan (1-isoPT) and 1-butyltryptophan (1-BT) were synthesized from tryptophan. We examined whether those compounds had the antiproliferative effects on SGC7901 and HeLa cells line by using MTT assay in vitro, respectively. Compared to tryptophan, all targeted compounds efficiently inhibited proliferation of two cancer cell lines at 2 mmol/L for 48 hours. Among these tryptophan analogs, 1-BT showed the most powerful cytotoxicity against SGC7901 and HeLa cells at 1 mmol/L and 2 mmol/L concentration. These data suggest that some specific tryptophan analogs could be developed as potential anti-neoplastic agents.
Keywords: tryptophan analogs; cytotoxicity; MTT tryptophan analogs; cytotoxicity; MTT
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Sun, T.; Li, Z.-L.; Tian, H.; Wang, S.-C.; Cai, J. Synthesis and Biological Evaluation of Novel 1-Alkyltryptophan Analogs as Potential Antitumor Agents. Molecules 2009, 14, 5339-5348.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top